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Query: LATS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LATS1 0 1.261 0.520 -0.880

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LATS1 Phosphorylation S278 0.261 0.599 _RYS(ph)GNM(ox)EYVISR_
LATS1 Phosphorylation S613 0.270 0.155 _KQITTS(ph)PITVR_
LATS1 Phosphorylation S464 0.077 -0.151 _SNS(ph)FNNPLGNR_
LATS1 Phosphorylation T262 -1.011 _GTT(ph)PPPPSWEPNSQTK_
LATS1 Phosphorylation T246 -2.282 _SVT(ph)PPPPPR_
LATS1 Phosphorylation S462 -0.408 _S(ph)NSFNNPLGNR_
LATS1 Ubiquitylation K688 0.392 _MLCQK(gl)ESNYIR_

Background Information for LATS1:


Pubmed-LATS1 »
Uniprot-LATS1 »
Biogrid-LATS1 »
ProteomicsDB-LATS1 »

Tumorportal-LATS1 »
COSMIC-LATS1 »
GenomeRNAi-LATS1 »
Genecards-LATS1


Protein-protein Interactions for LATS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MOBKL1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LATS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBA/Ts_N IPR000449 0.34
Category members UBA-like IPR009060 0.17
Category members UBA/transl_elong_EF1B_N_euk IPR015940 0.04
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring LATS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5317 LATS1-HTRA2-BIRC4 complex Database 0


Categories featuring LATS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0035329 hippo signaling Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_1013 REACTOME_SIGNALING_BY_HIPPO 0 0.63
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0000819 sister chromatid segregation Database 0.17
Category members GO Category GO:0051220 cytoplasmic sequestering of protein Database 0.17
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0009755 hormone-mediated signaling pathway Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0030833 regulation of actin filament polymerization Database 0
Category members GO Category GO:0043254 regulation of protein complex assembly Database 0
Category members GO Category GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity Database 0


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