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REACTOME_SIGNALING_BY_HIPPO
(Pathway_1013)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
TJP1 2 -0.410 1.150
TJP1 2 -0.410 1.150 -0.039 -0.011
TJP1 2 -0.410 1.150
AMOTL1 2 -1.540 3.320 0.614 0.467 0.043
AMOTL1 2 -1.540 3.320
YWHAE 1 0.440 -0.380 1.095 -0.160
YWHAE 1 0.440 -0.380 1.129 0.621 0.321
MOB1B 1 -1.680 3.090 -1.114 -0.379
DVL2 0 -0.050 0.580
STK4 0 0.260 -0.240
STK4 0 0.260 -0.240
STK4 0 0.260 -0.240 -0.235 -0.851
STK3 0 -0.570 0.720
STK3 0 -0.570 0.720 -0.235 -0.851
MOB1A 0 -0.400 0.780 -1.114 -0.379
TJP2 0 0.160 0.070 -1.237 -1.460
TJP2 0 0.160 0.070 0.144 0.035 0.024
AMOT 0 1.330 -0.510 0.614 0.467 0.043
AMOT 0 1.330 -0.510
LATS1 0 0.520 -0.880
YAP1 0 1.010 -0.370
SAV1 0 1.110 -0.700
CASP3 0 0.570 -0.390
YWHAB 0 0.628 -0.543
YWHAB 0 0.507 0.271 0.503

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AMOT Ubiquitylation K94 -0.138 _QEPQGQEIQSENLIMEK(gl)QLSPR_
AMOT Ubiquitylation K113 -0.211 0.313 _MQNNEELPTYEEAK(gl)VQSQYFR_
AMOT Ubiquitylation K503 -0.204 _NK(gl)LEGEIR_
AMOT Phosphorylation S712 0.161 0.250 _DTTVIS(ph)HSPNTSYDTALEAR_
AMOT Phosphorylation S714 0.324 0.183 _DTTVISHS(ph)PNTSYDTALEAR_
AMOTL1 Ubiquitylation K94 -0.138 _QEPQGQEIQSENLIMEK(gl)QLSPR_
AMOTL1 Ubiquitylation K113 -0.211 0.313 _MQNNEELPTYEEAK(gl)VQSQYFR_
AMOTL1 Ubiquitylation K174 -0.710 _QEPQGQEHQVDNTVMEK(gl)QVR_
AMOTL1 Ubiquitylation K227 0.218 _GQQQQQQQQGAVGHGYYMAGGTSQK(gl)SR_
AMOTL1 Ubiquitylation K251 -0.083 _ANSGQAHKDEALK(gl)ELK_
AMOTL1 Phosphorylation S269 0.526 _IMQLS(ph)LER_
AMOTL1 Ubiquitylation K302 -1.446 -1.374 _VGGGPSPAQPAGK(gl)VLDPR_
AMOTL1 Ubiquitylation K316 -0.341 _GPPPEYPFK(gl)TK_
AMOTL1 Ubiquitylation K318 0.088 0.953 _TK(gl)QMMSPVSK_
AMOTL1 Ubiquitylation K474 1.416 1.608 _FEK(gl)ELQR_
AMOTL1 Ubiquitylation K503 -0.204 _NK(gl)LEGEIR_
AMOTL1 Ubiquitylation K625 1.158 1.703 _LQQALTQLQSACEK(gl)R_
AMOTL1 Phosphorylation S712 0.161 0.250 _DTTVIS(ph)HSPNTSYDTALEAR_
AMOTL1 Phosphorylation S714 0.324 0.183 _DTTVISHS(ph)PNTSYDTALEAR_
AMOTL1 Phosphorylation S720 0.743 0.380 _DTTIINHS(ph)R_
CASP3 Ubiquitylation K11 -0.053 -0.687 _(ac)MENTENSVDSK(gl)SIK_
CASP3 Ubiquitylation K14 -0.455 -0.687 _SIK(gl)NLEPK_
CASP3 Ubiquitylation K57 -0.304 -1.817 _NFHK(gl)STGMTSR_
CASP3 Ubiquitylation K82 -0.268 -0.605 _NLK(gl)YEVR_
DVL2 Ubiquitylation K343 0.846 -1.366 _DIVHK(gl)PGPIVLTVAK_
LATS1 Phosphorylation T246 -2.282 _SVT(ph)PPPPPR_
LATS1 Phosphorylation T262 -1.011 _GTT(ph)PPPPSWEPNSQTK_
LATS1 Phosphorylation S278 0.261 0.599 _RYS(ph)GNM(ox)EYVISR_
LATS1 Phosphorylation S462 -0.408 _S(ph)NSFNNPLGNR_
LATS1 Phosphorylation S464 0.077 -0.151 _SNS(ph)FNNPLGNR_
LATS1 Phosphorylation S613 0.270 0.155 _KQITTS(ph)PITVR_
LATS1 Ubiquitylation K688 0.392 _MLCQK(gl)ESNYIR_
SAV1 Phosphorylation S27 1.144 _KETS(ph)PLLR_
STK3 Ubiquitylation K176 -0.350 _DIK(gl)AGNILLNTEGHAK_
STK3 Ubiquitylation K205 -0.223 -0.386 _LADFGVAGQLTDTMAK(gl)R_
STK3 Phosphorylation S344 0.416 0.115 _ELEEEEENS(ph)DEDELDSHTM(ox)VK_
STK3 Phosphorylation S344 0.573 0.366 _EMDQDDEENS(ph)EEDEMDSGTMVR_
STK3 Phosphorylation S413 0.603 1.205 _NATS(ph)PQVQRPSFMDYFDK_
STK3 Ubiquitylation K481 -0.782 _LK(gl)ALDPMMER_
STK4 Ubiquitylation K176 -0.350 _DIK(gl)AGNILLNTEGHAK_
STK4 Ubiquitylation K205 -0.223 -0.386 _LADFGVAGQLTDTMAK(gl)R_
STK4 Phosphorylation S320 0.555 0.552 _EVDQDDEENS(ph)EEDEMDSGTM(ox)VR_
STK4 Phosphorylation S344 0.573 0.366 _EMDQDDEENS(ph)EEDEMDSGTMVR_
TJP1 Ubiquitylation K54 0.081 -0.398 _GSLLPLK(gl)R_
TJP1 Ubiquitylation K157 0.023 -0.755 _SEK(gl)IWPR_
TJP1 Phosphorylation S175 0.113 -0.041 _S(ph)VASSQPAKPTK_
TJP1 Ubiquitylation K187 -0.394 _SVASSQPAK(gl)PTK_
TJP1 Ubiquitylation K198 0.760 0.143 _SRK(gl)NEEYGLR_
TJP1 Phosphorylation S329 -0.569 -0.354 _HS(ph)PQQPSNGSLR_
TJP1 Phosphorylation S353 -0.522 -0.375 _ISKPGAVS(ph)TPVK_
TJP1 Phosphorylation S617 0.438 0.543 _S(ph)REDLSAQPVQTK_
TJP1 Ubiquitylation K677 -0.484 _EEPDIYQIAK(gl)SEPR_
TJP1 Phosphorylation S912 -0.113 _IDS(ph)PGFKPASQQK_
TJP1 Phosphorylation S916 -0.049 0.102 _IDS(ph)PGFKPASQQVYR_
TJP1 Ubiquitylation K920 7.379 6.153 _IDSPGFK(gl)PASQQVYR_
TJP1 Phosphorylation S968 -0.778 _LEEPTPAPSTSYS(ph)PQADSLR_
TJP1 Phosphorylation S1579 0.045 -0.197 _SHS(ph)LAQPPEFDSGVETFSIHAEKPK_
TJP1 Phosphorylation S1617 0.665 _AIPVS(ph)PSAVEEDEDEDGHTVVATAR_
TJP2 Phosphorylation S161 -0.169 -0.024 _VQVAALQAS(ph)PPLDQDDR_
TJP2 Phosphorylation S205 0.118 0.563 _SWEDS(ph)PER_
TJP2 Phosphorylation S275 0.891 0.690 _GRS(ph)IDQDYER_
TJP2 Phosphorylation S297 0.478 0.579 _AYS(ph)PEYR_
TJP2 Phosphorylation S446 0.631 _SFS(ph)PEER_
TJP2 Phosphorylation S471 -0.863 0.159 _ERPS(ph)SREDTPSR_
TJP2 Phosphorylation S472 -0.715 0.193 _ERPSS(ph)REDTPSR_
TJP2 Ubiquitylation K506 -0.355 -0.981 _STGDIAGTVVPETNK(gl)EPR_
TJP2 Ubiquitylation K520 -1.549 _YQEEPPAPQPK(gl)AAPR_
TJP2 Ubiquitylation K800 -0.173 0.403 _DAGSEK(gl)STGVVR_
TJP2 Phosphorylation S992 -0.733 _SSEPVQHEES(ph)IRKPSPEPR_
TJP2 Phosphorylation S997 -1.075 -0.616 _SSEPVQHEESIRKPS(ph)PEPR_
TJP2 Phosphorylation S1017 -1.379 -1.918 _DNS(ph)PPPAFKPEPPK_
TJP2 Ubiquitylation K1047 -0.374 -0.833 _SYEYK(gl)SNPSAVAGNETPGASTK_
TJP2 Phosphorylation S1187 0.856 _GS(ph)YGSDAEEEEYRQQLSEHSK_
TJP2 Phosphorylation S1190 0.754 0.727 _GSYGS(ph)DAEEEEYRQQLSEHSK_
YAP1 Phosphorylation S61 -0.064 0.017 _GDS(ph)ETDLEALFNAVMNPK_
YAP1 Phosphorylation T63 -0.159 -0.257 _GDSET(ph)DLEALFNAVM(ox)NPK_
YAP1 Phosphorylation T110 0.467 _QAST(ph)DAGTAGALTPQHVR_
YAP1 Phosphorylation S127 -1.544 _AHS(ph)SPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR_
YAP1 Phosphorylation S131 -1.256 -1.096 _AHSSPAS(ph)LQLGAVSPGTLTPTGVVSGPAATPTAQHLR_
YAP1 Ubiquitylation K315 -0.002 _LQQLQMEK(gl)ER_
YAP1 Ubiquitylation K321 -1.043 _LK(gl)QQELLR_
YAP1 Ubiquitylation K342 -0.589 _NINPSTANSPK(gl)CQELALR_
YAP1 Phosphorylation S367 0.272 _SQLPTLEQDGGTQNPVSS(ph)PGMSQELR_
YAP1 Phosphorylation S397 -0.200 _DES(ph)TDSGLSM(ox)SSYSVPR_
YWHAB Ubiquitylation K11 1.057 1.322 _(ac)TMDKSELVQK(gl)AK_
YWHAB Ubiquitylation K13 0.060 0.388 _AK(gl)LAEQAER_
YWHAB Ubiquitylation K70 0.558 -0.175 _VISSIEQK(gl)TER_
YWHAB Ubiquitylation K140 0.531 _YLSEVASGDNK(gl)QTTVSNSQQAYQEAFEISKK_
YWHAB Ubiquitylation K159 0.300 _QTTVSNSQQAYQEAFEISK(gl)K_
YWHAB Ubiquitylation K160 -0.439 -0.371 _K(gl)EMQPTHPIR_
YWHAE Ubiquitylation K38 0.710 1.822 _YDEMVESMK(gl)K_
YWHAE Ubiquitylation K39 1.734 _YDEMVESMKK(gl)_
YWHAE Ubiquitylation K60 0.554 1.732 _NLLSVAYK(gl)NVIGAR_
YWHAE Ubiquitylation K83 0.375 0.643 _IISSIEQKEENK(gl)GGEDKLK_
YWHAE Ubiquitylation K90 1.103 _GGEDKLK(gl)MIR_
YWHAE Ubiquitylation K116 -0.289 _LICCDILDVLDK(gl)HLIPAANTGESK_
YWHAE Ubiquitylation K133 0.653 1.264 _VFYYK(gl)M(ox)K_
YWHAE Ubiquitylation K152 0.031 0.601 _K(gl)EAAENSLVAYK_
YWHAE Phosphorylation S210 0.534 0.506 _AAFDDAIAELDTLS(ph)EESYK_
YWHAE Phosphorylation S213 0.541 _AAFDDAIAELDTLSEES(ph)YK_


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