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Query: DVL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DVL2 0 0.060 -0.050 0.580

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DVL2 Ubiquitylation K343 0.846 -1.366 _DIVHK(gl)PGPIVLTVAK_

Background Information for DVL2:


Pubmed-DVL2 »
Uniprot-DVL2 »
Biogrid-DVL2 »
ProteomicsDB-DVL2 »

Tumorportal-DVL2 »
COSMIC-DVL2 »
GenomeRNAi-DVL2 »
Genecards-DVL2


Protein-protein Interactions for DVL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait DVL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DVL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DVL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OLFM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWOX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DVL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PDZ IPR001478 0.15
Category members DEP_dom IPR000591 0.07
Category members DIX IPR001158 0
Category members Dishevelled_protein_dom IPR003351 0
Category members Dishevelled_fam IPR008339 0
Category members Dishevelled_C-dom IPR024580 0


Protein complexes (CORUM database) featuring DVL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DVL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0035329 hippo signaling Database 0.68
Category members Pathway Pathway_671 PID_WNT_CANONICAL_PATHWAY 0 0.64
Category members Pathway Pathway_1013 REACTOME_SIGNALING_BY_HIPPO 0 0.63
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_417 PID_WNT_NONCANONICAL_PATHWAY 0 0.09
Category members GO Category GO:0043621 protein self-association Database 0.07
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0061098 positive regulation of protein tyrosine kinase activity Database 0.04
Category members GO Category GO:0060071 Wnt signaling pathway, planar cell polarity pathway Database 0.02
Category members Pathway Pathway_1175 PID_BETA_CATENIN_DEG_PATHWAY 0 0.01
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005109 frizzled binding Database 0
Category members GO Category GO:0007379 segment specification Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0021535 cell migration in hindbrain Database 0
Category members GO Category GO:0022007 convergent extension involved in neural plate elongation Database 0
Category members GO Category GO:0035282 segmentation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0035567 non-canonical Wnt signaling pathway Database 0
Category members GO Category GO:0043507 positive regulation of JUN kinase activity Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0060026 convergent extension Database 0
Category members GO Category GO:0060029 convergent extension involved in organogenesis Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0


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