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Query: AMOTL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AMOTL1 2 8.832 -1.540 3.320
AMOTL1 2 8.832 -1.540 3.320 0.614 0.467 0.043

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AMOTL1 Ubiquitylation K625 1.158 1.703 _LQQALTQLQSACEK(gl)R_
AMOTL1 Ubiquitylation K474 1.416 1.608 _FEK(gl)ELQR_
AMOTL1 Ubiquitylation K318 0.088 0.953 _TK(gl)QMMSPVSK_
AMOTL1 Phosphorylation S269 0.526 _IMQLS(ph)LER_
AMOTL1 Phosphorylation S720 0.743 0.380 _DTTIINHS(ph)R_
AMOTL1 Ubiquitylation K113 -0.211 0.313 _MQNNEELPTYEEAK(gl)VQSQYFR_
AMOTL1 Phosphorylation S712 0.161 0.250 _DTTVIS(ph)HSPNTSYDTALEAR_
AMOTL1 Ubiquitylation K227 0.218 _GQQQQQQQQGAVGHGYYMAGGTSQK(gl)SR_
AMOTL1 Phosphorylation S714 0.324 0.183 _DTTVISHS(ph)PNTSYDTALEAR_
AMOTL1 Ubiquitylation K302 -1.446 -1.374 _VGGGPSPAQPAGK(gl)VLDPR_
AMOTL1 Ubiquitylation K94 -0.138 _QEPQGQEIQSENLIMEK(gl)QLSPR_
AMOTL1 Ubiquitylation K174 -0.710 _QEPQGQEHQVDNTVMEK(gl)QVR_
AMOTL1 Ubiquitylation K251 -0.083 _ANSGQAHKDEALK(gl)ELK_
AMOTL1 Ubiquitylation K316 -0.341 _GPPPEYPFK(gl)TK_
AMOTL1 Ubiquitylation K503 -0.204 _NK(gl)LEGEIR_

Background Information for AMOTL1:


Pubmed-AMOTL1 »
Uniprot-AMOTL1 »
Biogrid-AMOTL1 »
ProteomicsDB-AMOTL1 »

Tumorportal-AMOTL1 »
COSMIC-AMOTL1 »
GenomeRNAi-AMOTL1 »
Genecards-AMOTL1


Protein-protein Interactions for AMOTL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AMOT Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait YAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALOX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FHL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPP5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AMOTL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Angiomotin IPR009114 0.05
Category members Angiomotin_C IPR024646 0.05


Protein complexes (CORUM database) featuring AMOTL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 848 RICH1/AMOT polarity complex, Flag-Amot precipitated Database 0.35


Categories featuring AMOTL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0008180 COP9 signalosome Database 1.47
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0035329 hippo signaling Database 0.68
Category members Pathway Pathway_1013 REACTOME_SIGNALING_BY_HIPPO 0 0.63
Category members GO Category GO:0003365 establishment of cell polarity involved in ameboidal cell migration Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0043536 positive regulation of blood vessel endothelial cell migration Database 0.09
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0


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