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Query: TJP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TJP1 2 15.840 -0.410 1.150
TJP1 2 15.840 -0.410 1.150 -0.039 -0.011

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TJP1 Ubiquitylation K920 7.379 6.153 _IDSPGFK(gl)PASQQVYR_
TJP1 Phosphorylation S617 0.438 0.543 _S(ph)REDLSAQPVQTK_
TJP1 Ubiquitylation K198 0.760 0.143 _SRK(gl)NEEYGLR_
TJP1 Phosphorylation S916 -0.049 0.102 _IDS(ph)PGFKPASQQVYR_
TJP1 Phosphorylation S175 0.113 -0.041 _S(ph)VASSQPAKPTK_
TJP1 Phosphorylation S912 -0.113 _IDS(ph)PGFKPASQQK_
TJP1 Phosphorylation S1579 0.045 -0.197 _SHS(ph)LAQPPEFDSGVETFSIHAEKPK_
TJP1 Phosphorylation S329 -0.569 -0.354 _HS(ph)PQQPSNGSLR_
TJP1 Phosphorylation S353 -0.522 -0.375 _ISKPGAVS(ph)TPVK_
TJP1 Ubiquitylation K54 0.081 -0.398 _GSLLPLK(gl)R_
TJP1 Ubiquitylation K157 0.023 -0.755 _SEK(gl)IWPR_
TJP1 Phosphorylation S968 -0.778 _LEEPTPAPSTSYS(ph)PQADSLR_
TJP1 Phosphorylation S1617 0.665 _AIPVS(ph)PSAVEEDEDEDGHTVVATAR_
TJP1 Ubiquitylation K187 -0.394 _SVASSQPAK(gl)PTK_
TJP1 Ubiquitylation K677 -0.484 _EEPDIYQIAK(gl)SEPR_

Background Information for TJP1:


Pubmed-TJP1 »
Uniprot-TJP1 »
Biogrid-TJP1 »
ProteomicsDB-TJP1 »

Tumorportal-TJP1 »
COSMIC-TJP1 »
GenomeRNAi-TJP1 »
Genecards-TJP1


Protein-protein Interactions for TJP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait MPHOSPH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CGN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYBA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFI30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGIX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UQCRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TJP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members GK/Ca_channel_bsu IPR008145 1.36
Category members Guanylate_kin-like IPR008144 1.32
Category members PDZ IPR001478 0.15
Category members SH3_2 IPR011511 0.08
Category members ZonOcculdens IPR005417 0.04
Category members ZU5_dom IPR000906 0
Category members SH3_domain IPR001452 0


Protein complexes (CORUM database) featuring TJP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 5772 ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex Database 0


Categories featuring TJP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0035329 hippo signaling Database 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members Pathway Pathway_1013 REACTOME_SIGNALING_BY_HIPPO 0 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0007043 cell-cell junction assembly Database 0.31
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members GO Category GO:0043296 apical junction complex Database 0.18
Category members Pathway Pathway_1019 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 0 0.17
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members GO Category GO:0046581 intercellular canaliculus Database 0.15
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0001825 blastocyst formation Database 0.09
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0016327 apicolateral plasma membrane Database 0.04
Category members GO Category GO:0005921 gap junction Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0043116 negative regulation of vascular permeability Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0


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