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Query: STK4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STK4 0 -0.534 0.260 -0.240
STK4 0 -0.534 0.260 -0.240 -0.235 -0.851

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STK4 Phosphorylation S320 0.555 0.552 _EVDQDDEENS(ph)EEDEMDSGTM(ox)VR_
STK4 Phosphorylation S344 0.573 0.366 _EMDQDDEENS(ph)EEDEMDSGTMVR_
STK4 Ubiquitylation K176 -0.350 _DIK(gl)AGNILLNTEGHAK_
STK4 Ubiquitylation K205 -0.223 -0.386 _LADFGVAGQLTDTMAK(gl)R_

Background Information for STK4:


Pubmed-STK4 »
Uniprot-STK4 »
Biogrid-STK4 »
ProteomicsDB-STK4 »

Tumorportal-STK4 »
COSMIC-STK4 »
GenomeRNAi-STK4 »
Genecards-STK4


Protein-protein Interactions for STK4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADCYAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIF2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF133 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF695 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STK4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Mst1_SARAH_domain IPR024205 0.08
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members SARAH_dom IPR011524 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring STK4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring STK4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0035329 hippo signaling Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_1013 REACTOME_SIGNALING_BY_HIPPO 0 0.63
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0043539 protein serine/threonine kinase activator activity Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0060215 primitive hemopoiesis Database 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0003157 endocardium development Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0001841 neural tube formation Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046621 negative regulation of organ growth Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0060706 cell differentiation involved in embryonic placenta development Database 0


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