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Query: YWHAE

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
YWHAE 1 7.005 0.440 -0.380 1.095 -0.160
YWHAE 1 7.005 0.440 -0.380 1.129 0.621 0.321

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
YWHAE Ubiquitylation K38 0.710 1.822 _YDEMVESMK(gl)K_
YWHAE Ubiquitylation K39 1.734 _YDEMVESMKK(gl)_
YWHAE Ubiquitylation K60 0.554 1.732 _NLLSVAYK(gl)NVIGAR_
YWHAE Ubiquitylation K133 0.653 1.264 _VFYYK(gl)M(ox)K_
YWHAE Ubiquitylation K83 0.375 0.643 _IISSIEQKEENK(gl)GGEDKLK_
YWHAE Ubiquitylation K152 0.031 0.601 _K(gl)EAAENSLVAYK_
YWHAE Phosphorylation S213 0.541 _AAFDDAIAELDTLSEES(ph)YK_
YWHAE Phosphorylation S210 0.534 0.506 _AAFDDAIAELDTLS(ph)EESYK_
YWHAE Ubiquitylation K90 1.103 _GGEDKLK(gl)MIR_
YWHAE Ubiquitylation K116 -0.289 _LICCDILDVLDK(gl)HLIPAANTGESK_

Background Information for YWHAE:


Pubmed-YWHAE »
Uniprot-YWHAE »
Biogrid-YWHAE »
ProteomicsDB-YWHAE »

Tumorportal-YWHAE »
COSMIC-YWHAE »
GenomeRNAi-YWHAE »
Genecards-YWHAE


Protein-protein Interactions for YWHAE
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC88A Cat. description Hein, Mann, Cell 2015
Category members IP bait MAP3K2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH11 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRICKLE3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSNAX Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAH Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAZ Cat. description Hein, Mann, Cell 2015
Category members IP bait BRAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CGN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRTC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPB49 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM163A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0748 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0930 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NKD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PAK6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLEKHG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRICKLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SAMD4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SAMD4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMTNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFEB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in YWHAE
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 14/03/2003 IPR000308 1.96
Category members 14-3-3_domain IPR023410 1.96


Protein complexes (CORUM database) featuring YWHAE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5199 Kinase maturation complex 1 Database 3.38
Category members Corum 5919 BRAF-RAF1-14-3-3 complex Database 1.97
Category members Corum 5615 Emerin complex 52 Database 0.99
Category members Corum 5873 RAF1-MAP2K1-YWHAE complex Database 0.35
Category members Corum 5877 MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex Database 0.31
Category members Corum 2145 HSF1-YWHAE complex Database 0.24
Category members Corum 5872 BRAF-MAP2K1-MAP2K2-YWHAE complex Database 0.06
Category members Corum 5613 Emerin complex 25 Database 0.04


Categories featuring YWHAE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_729 PID_LIS1_PATHWAY 0 1.41
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0035329 hippo signaling Database 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_1013 REACTOME_SIGNALING_BY_HIPPO 0 0.63
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0006605 protein targeting Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005871 kinesin complex Database 0.27
Category members Disease phenotype 17p13.3_microduplication_syndrome 17p13.3 microduplication syndrome Database 0.24
Category members Disease phenotype Miller-Dieker_syndrome Miller-Dieker syndrome Database 0.24
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0003064 regulation of heart rate by hormone Database 0
Category members GO Category GO:0015459 potassium channel regulator activity Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0035308 negative regulation of protein dephosphorylation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0050815 phosphoserine binding Database 0
Category members GO Category GO:0060306 regulation of membrane repolarization Database 0


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