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Query: PML

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PML 1 4.910 -0.420 0.350 -0.244 0.322

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PML Phosphorylation S403 3.141 _KAS(ph)PEAASTPRDPIDVDLPEEAER_
PML Ubiquitylation K394 0.515 0.360 _LQDLSSCITQGK(gl)DAAVSKK_
PML Phosphorylation S530 0.466 0.093 _S(ph)PVIGSEVFLPNSNHVASGAGEAEER_
PML Phosphorylation S504 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S505 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Ubiquitylation K476 -0.403 -0.735 _GPSYGEDVSNTTTAQK(gl)R_
PML Ubiquitylation K623 -0.784 _IDNETQK(gl)ISQLAAVNR_
PML Phosphorylation S518 -1.632 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S527 -1.392 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_

Background Information for PML:


Pubmed-PML »
Uniprot-PML »
Biogrid-PML »
ProteomicsDB-PML »

Tumorportal-PML »
COSMIC-PML »
GenomeRNAi-PML »
Genecards-PML


Protein-protein Interactions for PML
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C20orf172;DSN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CASC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ESPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FIP1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KRAS Cat. description Hein, Mann, Cell 2015
Category members IP bait PML Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait USP7 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACOT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGEF16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PADI3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIML2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PML
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_B-box IPR000315 0
Category members Znf_RING IPR001841 0


Protein complexes (CORUM database) featuring PML
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1827 PML-SMAD2/3-SARA complex Database 0.01
Category members Corum 1055 ZNF198-PML complex Database 0


Categories featuring PML
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0032183 SUMO binding Database 0.45
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Disease phenotype ACUTE_PROMYELOCYTIC_LEUKEMIA ACUTE PROMYELOCYTIC LEUKEMIA Database 0.39
Category members GO Category GO:0030578 PML body organization Database 0.39
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006605 protein targeting Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0031065 positive regulation of histone deacetylation Database 0.21
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members GO Category GO:0045343 regulation of MHC class I biosynthetic process Database 0.15
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0060058 positive regulation of apoptotic process involved in mammary gland involution Database 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0007184 SMAD protein import into nucleus Database 0.08
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members Pathway Pathway_1062 BIOCARTA_PML_PATHWAY 0 0.06
Category members GO Category GO:0051457 maintenance of protein location in nucleus Database 0.05
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0001932 regulation of protein phosphorylation Database 0.04
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0045930 negative regulation of mitotic cell cycle Database 0.01
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_898 REACTOME_INTERFERON_GAMMA_SIGNALING 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0002230 positive regulation of defense response to virus by host Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007182 common-partner SMAD protein phosphorylation Database 0
Category members GO Category GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress Database 0
Category members GO Category GO:0016525 negative regulation of angiogenesis Database 0
Category members GO Category GO:0030099 myeloid cell differentiation Database 0
Category members GO Category GO:0032211 negative regulation of telomere maintenance via telomerase Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0048384 retinoic acid receptor signaling pathway Database 0
Category members GO Category GO:0050897 cobalt ion binding Database 0
Category members GO Category GO:0051974 negative regulation of telomerase activity Database 0
Category members GO Category GO:0060333 interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060444 branching involved in mammary gland duct morphogenesis Database 0


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