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intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
SOD2 1 -0.340 0.140 2.161 -0.330
PML 1 -0.420 0.350 -0.244 0.322
STK24 0 0.490 -0.300 -0.371 0.364
STK24 0 0.490 -0.300 -0.052
STK24 0 0.490 -0.300
UACA 0 -0.200 -0.170 0.298 0.359
PDK1 0 0.150 -0.470 -0.026 -0.562 0.355 0.460
CASP3 0 0.570 -0.390
MELK 0 -0.620 0.710 -0.249 -0.278
BCL2 0 0.910 -0.740
DIABLO 0 0.740 -0.290 0.517 0.500
DIABLO 0 0.740 -0.290 -0.061
MAP3K5 0 0.710 -0.770

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
BCL2 Ubiquitylation K22 1.480 _YIHYK(gl)LSQR_
CASP3 Ubiquitylation K11 -0.053 -0.687 _(ac)MENTENSVDSK(gl)SIK_
CASP3 Ubiquitylation K14 -0.455 -0.687 _SIK(gl)NLEPK_
CASP3 Ubiquitylation K57 -0.304 -1.817 _NFHK(gl)STGMTSR_
CASP3 Ubiquitylation K82 -0.268 -0.605 _NLK(gl)YEVR_
MAP3K5 Phosphorylation S1066 -1.241 _SISLPVPVLVEDTSSSSEYGSVS(ph)PDTELKVDPFSFK_
MAP3K5 Phosphorylation S1113 -1.408 -0.562 _TLFLGIPDENFEDHSAPPS(ph)PEEK_
MELK Ubiquitylation K55 -0.604 _IK(gl)TEIEALK_
MELK Ubiquitylation K419 -1.760 _TPANK(gl)LK_
MELK Ubiquitylation K597 -0.858 _GYTLK(gl)CQTQSDFGK_
MELK Ubiquitylation K650 -0.307 _LVEDILSSCK(gl)V_
PML Ubiquitylation K394 0.515 0.360 _LQDLSSCITQGK(gl)DAAVSKK_
PML Phosphorylation S403 3.141 _KAS(ph)PEAASTPRDPIDVDLPEEAER_
PML Ubiquitylation K476 -0.403 -0.735 _GPSYGEDVSNTTTAQK(gl)R_
PML Phosphorylation S504 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S505 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S518 -1.632 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S527 -1.392 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S530 0.466 0.093 _S(ph)PVIGSEVFLPNSNHVASGAGEAEER_
PML Ubiquitylation K623 -0.784 _IDNETQK(gl)ISQLAAVNR_
STK24 Phosphorylation S4 0.269 0.161 _(ac)AHS(ph)PVAVQVPGMQNNIADPEELFTK_
STK24 Phosphorylation S4 0.816 0.517 _(ac)AHS(ph)PVQSGLPGMQNLK_
STK24 Ubiquitylation K162 -0.327 0.155 _GLDYLHSEKK(gl)_
STK24 Ubiquitylation K197 -0.399 0.038 _LADFGVAGQLTDTQIK(gl)R_
STK24 Ubiquitylation K255 -0.986 _VLFLIPK(gl)NNPPTLVGDFTK_
STK24 Ubiquitylation K298 0.008 -0.419 _FIVK(gl)NSK_
STK24 Ubiquitylation K302 -0.101 0.068 _K(gl)TSYLTELIDR_
STK24 Ubiquitylation K420 -0.470 _SIAVAEAACPGITDK(gl)MVK_
STK24 Ubiquitylation K423 -0.470 -0.024 _SIAVAEAACPGITDKMVK(gl)_


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