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Query: MELK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MELK 0 -0.728 -0.620 0.710 -0.249 -0.278

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MELK Ubiquitylation K55 -0.604 _IK(gl)TEIEALK_
MELK Ubiquitylation K597 -0.858 _GYTLK(gl)CQTQSDFGK_
MELK Ubiquitylation K419 -1.760 _TPANK(gl)LK_
MELK Ubiquitylation K650 -0.307 _LVEDILSSCK(gl)V_

Background Information for MELK:


Pubmed-MELK »
Uniprot-MELK »
Biogrid-MELK »
ProteomicsDB-MELK »

Tumorportal-MELK »
COSMIC-MELK »
GenomeRNAi-MELK »
Genecards-MELK


Protein-protein Interactions for MELK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBWD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAVCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLST8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLAUR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PROZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHPN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPACA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MELK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members KA1/Ssp2_C IPR028375 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members KA1_dom IPR001772 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members LipoPS_kinase IPR010440 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring MELK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MELK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress Database 0
Category members GO Category GO:0009103 lipopolysaccharide biosynthetic process Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0061351 neural precursor cell proliferation Database 0


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