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Query: PDK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDK1 0 0.227 0.150 -0.470 -0.026 -0.562 0.355 0.460

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for PDK1:


Pubmed-PDK1 »
Uniprot-PDK1 »
Biogrid-PDK1 »
ProteomicsDB-PDK1 »

Tumorportal-PDK1 »
COSMIC-PDK1 »
GenomeRNAi-PDK1 »
Genecards-PDK1


Protein-protein Interactions for PDK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC93 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACAD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APLNR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf90 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC18A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT61B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PDK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HATPase_C IPR003594 1.07
Category members Sig_transdc_His_kinase_core IPR005467 0.2
Category members BCDHK/PDK_N IPR018955 0.2


Protein complexes (CORUM database) featuring PDK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity Database 0.48
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members Pathway Pathway_625 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0 0.26
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0010906 regulation of glucose metabolic process Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members Pathway Pathway_514 ST_GAQ_PATHWAY 0 0.17
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_14 REACTOME_PYRUVATE_METABOLISM 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0006090 pyruvate metabolic process Database 0.04
Category members Pathway Pathway_15 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_619 SA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_633 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members GO Category GO:0005967 mitochondrial pyruvate dehydrogenase complex Database 0
Category members GO Category GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress Database 0
Category members GO Category GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate Database 0


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