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Query: BCL2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCL2 0 1.480 0.910 -0.740

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCL2 Ubiquitylation K22 1.480 _YIHYK(gl)LSQR_

Background Information for BCL2:


Pubmed-BCL2 »
Uniprot-BCL2 »
Biogrid-BCL2 »
ProteomicsDB-BCL2 »

Tumorportal-BCL2 »
COSMIC-BCL2 »
GenomeRNAi-BCL2 »
Genecards-BCL2


Protein-protein Interactions for BCL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL2L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BCL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Blc2_fam IPR026298 0.14
Category members Bcl2-like IPR002475 0.05


Protein complexes (CORUM database) featuring BCL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1062 BAR-BCL2-CASP8 complex Database 0
Category members Corum 5526 CALM1-FKBP38-BCL2 complex Database 0


Categories featuring BCL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051881 regulation of mitochondrial membrane potential Database 1.57
Category members GO Category GO:0046930 pore complex Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_754 SA_PROGRAMMED_CELL_DEATH 0 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0010224 response to UV-B Database 0.44
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0003014 renal system process Database 0.35
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0046902 regulation of mitochondrial membrane permeability Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0031647 regulation of protein stability Database 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members GO Category GO:0007565 female pregnancy Database 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0006808 regulation of nitrogen utilization Database 0.17
Category members GO Category GO:0021747 cochlear nucleus development Database 0.17
Category members GO Category GO:0048087 positive regulation of developmental pigmentation Database 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0048066 developmental pigmentation Database 0.15
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0043496 regulation of protein homodimerization activity Database 0.12
Category members GO Category GO:0006582 melanin metabolic process Database 0.11
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0001952 regulation of cell-matrix adhesion Database 0.11
Category members GO Category GO:0051924 regulation of calcium ion transport Database 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members GO Category GO:0048041 focal adhesion assembly Database 0.1
Category members GO Category GO:0010559 regulation of glycoprotein biosynthetic process Database 0.09
Category members GO Category GO:0014911 positive regulation of smooth muscle cell migration Database 0.09
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0042100 B cell proliferation Database 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0043497 regulation of protein heterodimerization activity Database 0.07
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0031069 hair follicle morphogenesis Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0045069 regulation of viral genome replication Database 0.05
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members GO Category GO:0014031 mesenchymal cell development Database 0.04
Category members GO Category GO:0002326 B cell lineage commitment Database 0.04
Category members GO Category GO:0002931 response to ischemia Database 0.04
Category members GO Category GO:0048873 homeostasis of number of cells within a tissue Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0001782 B cell homeostasis Database 0.02
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0045930 negative regulation of mitotic cell cycle Database 0.01
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members GO Category GO:0001656 metanephros development Database 0
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_1017 BIOCARTA_HSP27_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_307 SA_FAS_SIGNALING 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_582 BIOCARTA_IL7_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_633 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_755 PID_RXR_VDR_PATHWAY 0 0
Category members Pathway Pathway_988 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members Disease phenotype Follicular_lymphoma Follicular lymphoma Database 0
Category members Disease phenotype Intravascular_large_B-cell_lymphoma Intravascular large B-cell lymphoma Database 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0001101 response to acid Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001662 behavioral fear response Database 0
Category members GO Category GO:0001776 leukocyte homeostasis Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0002260 lymphocyte homeostasis Database 0
Category members GO Category GO:0002320 lymphoid progenitor cell differentiation Database 0
Category members GO Category GO:0002360 T cell lineage commitment Database 0
Category members GO Category GO:0002520 immune system development Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0006959 humoral immune response Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress Database 0
Category members GO Category GO:0009605 response to external stimulus Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010039 response to iron ion Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010507 negative regulation of autophagy Database 0
Category members GO Category GO:0010523 negative regulation of calcium ion transport into cytosol Database 0
Category members GO Category GO:0014042 positive regulation of neuron maturation Database 0
Category members GO Category GO:0015267 channel activity Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0022612 gland morphogenesis Database 0
Category members GO Category GO:0022898 regulation of transmembrane transporter activity Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0030279 negative regulation of ossification Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0030318 melanocyte differentiation Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0031103 axon regeneration Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0032835 glomerulus development Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0033033 negative regulation of myeloid cell apoptotic process Database 0
Category members GO Category GO:0033689 negative regulation of osteoblast proliferation Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0035094 response to nicotine Database 0
Category members GO Category GO:0035265 organ growth Database 0
Category members GO Category GO:0040007 growth Database 0
Category members GO Category GO:0040018 positive regulation of multicellular organism growth Database 0
Category members GO Category GO:0042149 cellular response to glucose starvation Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043029 T cell homeostasis Database 0
Category members GO Category GO:0043067 regulation of programmed cell death Database 0
Category members GO Category GO:0043209 myelin sheath Database 0
Category members GO Category GO:0043473 pigmentation Database 0
Category members GO Category GO:0043583 ear development Database 0
Category members GO Category GO:0045636 positive regulation of melanocyte differentiation Database 0
Category members GO Category GO:0048070 regulation of developmental pigmentation Database 0
Category members GO Category GO:0048536 spleen development Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048546 digestive tract morphogenesis Database 0
Category members GO Category GO:0048599 oocyte development Database 0
Category members GO Category GO:0048743 positive regulation of skeletal muscle fiber development Database 0
Category members GO Category GO:0048753 pigment granule organization Database 0
Category members GO Category GO:0050790 regulation of catalytic activity Database 0
Category members GO Category GO:0050853 B cell receptor signaling pathway Database 0
Category members GO Category GO:0051434 BH3 domain binding Database 0
Category members GO Category GO:0051721 protein phosphatase 2A binding Database 0
Category members GO Category GO:0051902 negative regulation of mitochondrial depolarization Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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