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Query: VCP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VCP 2 5.570 1.650 -0.640 -0.182 0.578 -0.596 0.007 -0.036

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VCP Ubiquitylation K696 1.574 1.691 _ACK(gl)LAIR_
VCP Ubiquitylation K615 1.209 1.270 _VINQILTEMDGMSTKK(gl)_
VCP Ubiquitylation K389 0.568 1.195 _LEILQIHTKNMK(gl)_
VCP Phosphorylation S3 0.795 1.142 _(ac)AS(ph)GADSKGDDLSTAILK_
VCP Phosphorylation S7 0.312 0.941 _(ac)ASGADS(ph)KGDDLSTAILK_
VCP Ubiquitylation K754 0.510 0.939 _K(gl)YEMFAQTLQQSR_
VCP Ubiquitylation K211 1.383 0.902 _K(gl)QLAQIK_
VCP Ubiquitylation K505 0.377 0.794 _FLK(gl)FGMTPSK_
VCP Ubiquitylation K658 0.362 0.711 _VAILK(gl)ANLR_
VCP Ubiquitylation K386 1.339 0.706 _LEILQIHTK(gl)NM(ox)K_
VCP Ubiquitylation K565 0.645 0.689 _EIFDK(gl)AR_
VCP Ubiquitylation K20 -0.512 0.529 _(ac)ASGADSKGDDLSTAILKQK(gl)_
VCP Ubiquitylation K60 0.678 0.493 _GDTVLLK(gl)GKK_
VCP Ubiquitylation K668 -0.536 0.265 _SPVAK(gl)DVDLEFLAK_
VCP Ubiquitylation K18 -0.452 0.181 _GDDLSTAILK(gl)QK_
VCP Ubiquitylation K148 -0.262 -0.087 _K(gl)GDIFLVR_
VCP Ubiquitylation K8 -0.439 -0.154 _(ac)ASGADSK(gl)GDDLSTAILK_
VCP Ubiquitylation K236 -0.526 -0.178 _AIGVK(gl)PPR_
VCP Ubiquitylation K529 -0.250 _GVLFYGPPGCGKTLLAK(gl)_
VCP Ubiquitylation K109 -0.847 -0.260 _LGDVISIQPCPDVK(gl)YGK(gl)R_
VCP Ubiquitylation K112 -0.736 -0.276 _LGDVISIQPCPDVK(gl)YGK(gl)R_
VCP Ubiquitylation K524 -0.528 _GVLFYGPPGCGK(gl)TLLAK_
VCP Ubiquitylation K651 -1.709 -0.719 _LDQLIYIPLPDEK(gl)SR_
VCP Ubiquitylation K81 0.084 _EAVCIVLSDDTCSDEK(gl)IR_
VCP Ubiquitylation K251 -0.110 _GILLYGPPGTGK(gl)TLIAR_
VCP Ubiquitylation K336 0.522 _IVSQLLTLMDGLK(gl)QR_
VCP Ubiquitylation K663 -0.839 _K(gl)SPVAKDVDLEFLAK_

Background Information for VCP:





Protein-protein Interactions for VCP

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20A Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait PDK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait STMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VCP Cat. description Hein, Mann, Cell 2015
Category members IP bait VCPIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS18 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATG9A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSFL1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PARK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC17A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBL7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBXN2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBXN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBXN6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VCP

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members DNA_helicase_Holl-junc_RuvB_N IPR008824 1.05
Category members AAA+_ATPase IPR003593 0.38
Category members ATPase_AAA_core IPR003959 0.14
Category members CDC48_domain_2-like IPR029067 0.12
Category members Asp_de-COase-like_dom IPR009010 0.04
Category members Vps4_C IPR015415 0.02
Category members CDC4_N-term_subdom IPR003338 0
Category members Cdc48_dom2 IPR004201 0


Protein complexes (CORUM database) featuring VCP

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4999 p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex Database 0.52
Category members Corum 4976 SVIP-p97/VCP-DERL1 complex Database 0.46
Category members Corum 2820 BRCA1-VCP complex Database 0.36
Category members Corum 2837 Profilin 1 complex Database 0.21
Category members Corum 4977 gp78-p97/VCP-DERL1 complex Database 0.2
Category members Corum 4998 p97/VCP-VIMP-DERL2 complex Database 0.01
Category members Corum 4997 p97/VCP-VIMP-DERL1 complex Database 0
Category members Corum 5684 Membrane protein complex (DERL1, SELS, VCP) Database 0
Category members Corum 5685 Membrane protein complex (VCP, UFD1L, SEC61B) Database 0


Categories featuring VCP

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0000502 proteasome complex Database 3.17
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0009378 four-way junction helicase activity Database 1.06
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0031334 positive regulation of protein complex assembly Database 0.69
Category members GO Category GO:0035861 site of double-strand break Database 0.65
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0031593 polyubiquitin binding Database 0.38
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0030433 ER-associated ubiquitin-dependent protein catabolic process Database 0.33
Category members GO Category GO:0006888 ER to Golgi vesicle-mediated transport Database 0.28
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members Disease phenotype INCLUSION_BODY_MYOPATHY_WITH_EARLY-ONSET_PAGET_DISEASE_WITH_OR_WITHOUT INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT Database 0.11
Category members Disease phenotype Inclusion_body_myopathy_with_Paget_disease_of_bone_and_frontotemporal_dementia Inclusion body myopathy with Paget disease of bone and frontotemporal dementia Database 0.11
Category members GO Category GO:0045184 establishment of protein localization Database 0.1
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0030970 retrograde protein transport, ER to cytosol Database 0.06
Category members GO Category GO:0019985 translesion synthesis Database 0.05
Category members Disease phenotype Behavioral_variant_of_frontotemporal_dementia Behavioral variant of frontotemporal dementia Database 0.04
Category members Disease phenotype Progressive_non-fluent_aphasia Progressive non-fluent aphasia Database 0.04
Category members Disease phenotype Semantic_dementia Semantic dementia Database 0.04
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0070842 aggresome assembly Database 0


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