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Amyotrophic lateral sclerosis
(Amyotrophic_lateral_sclerosis)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
MATR3 2 0.330 -0.770 0.616 -1.792 -0.824 -0.795 -0.093
MATR3 2 0.330 -0.770 -0.059 -2.461 -1.002
VAPB 2 1.440 -0.660 0.042 0.495
VAPB 2 1.440 -0.660 -2.551 0.014 0.056
HNRNPA1 2 -1.640 2.570 0.075 -0.732 0.003
HNRNPA1 2 -1.290 1.410 0.075 -0.732 0.003
VCP 2 1.650 -0.640 -0.182 0.578 -0.596 0.007 -0.036
PFN1 1 -0.430 -0.180 0.002 2.497 -0.084 0.348 -0.059
PRPH 1 -1.000 1.640 -0.399 1.029
CHMP2B 0 -0.500 1.180
FUS 0 -0.360 0.760 -0.267 -1.116 0.302
PON2 0 -0.260 0.150 -0.822 0.003
DPYSL3 0 0.400 -0.420 -0.511
TARDBP 0 -1.050 1.160 -0.359 -1.276 -0.495 -0.408 0.021
OPTN 0
SOD1 0 1.450 -1.250
SQSTM1 0 -0.860 1.770 -2.165 -2.063 -1.741
SQSTM1 0 -0.440 0.530 -2.165 -2.063 -1.741
ERBB4 0
ERBB4 0
UBQLN2 0 -0.490 0.310 -1.311 -1.707 -0.954
ATXN2 0 -0.480 0.100 -1.858 -0.941 -0.424
DCTN1 0 1.450 -0.750 0.127
DCTN1 0 1.450 -0.750 -0.378 -2.511 0.436 0.352

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATXN2 Ubiquitylation K349 -0.862 0.369 _DMDSSYAK(gl)R_
ATXN2 Ubiquitylation K455 -1.801 _ANQLAEEIESSAQYK(gl)AR_
ATXN2 Phosphorylation S616 -0.891 _RM(ox)S(ph)SEGPPRM(ox)SPK_
ATXN2 Phosphorylation S624 -1.157 -0.461 _MSSEGPPRMS(ph)PK_
ATXN2 Phosphorylation S667 0.034 _TS(ph)PSGGTWSSVVSGVPR_
ATXN2 Phosphorylation S669 0.002 0.244 _TSPS(ph)GGTWSSVVSGVPR_
ATXN2 Phosphorylation T771 -0.128 -0.274 _QNSPAGNKENIKPNET(ph)SPSFSK_
ATXN2 Phosphorylation S772 -0.093 -0.116 _ENIKPNETS(ph)PSFSK_
ATXN2 Phosphorylation S784 -0.208 0.376 _GIS(ph)PVVSEHR_
ATXN2 Phosphorylation S889 -0.710 _RGPEVTSQGVQTSS(ph)PACK_
CHMP2B Ubiquitylation K195 -0.063 _SLPSASTSK(gl)ATISDEEIER_
CHMP2B Phosphorylation S199 0.711 0.812 _ATIS(ph)DEEIER_
DCTN1 Ubiquitylation K618 0.526 0.373 _LICK(gl)AELIR_
DPYSL3 Phosphorylation S102 -1.104 -0.731 _EESREPAPAS(ph)PAPAGVEIR_
DPYSL3 Phosphorylation T622 -0.228 _GM(ox)YDGPVFDLTT(ph)TPK_
DPYSL3 Phosphorylation T623 -0.604 -0.464 _GM(ox)YDGPVFDLTTT(ph)PK_
DPYSL3 Phosphorylation S636 -0.777 -0.696 _GS(ph)PTRPNPPVR_
ERBB4 Ubiquitylation K714 0.078 _ILK(gl)ETELKR_
ERBB4 Ubiquitylation K745 -0.474 0.342 _GIWVPEGETVK(gl)IPVAIK_
ERBB4 Ubiquitylation K854 -0.859 _NVLVK(gl)SPNHVK_
FUS Ubiquitylation K319 0.572 _K(gl)TGQPMINLYTDR_
HNRNPA1 Phosphorylation S2 -0.533 -0.660 _(ac)S(ph)KSES(ph)PKEPEQLR_
HNRNPA1 Ubiquitylation K3 -1.084 -0.893 _(ac)SK(gl)SESPKEPEQLR_
HNRNPA1 Phosphorylation S4 0.422 -0.360 _S(ph)ESPKEPEQLRK_
HNRNPA1 Phosphorylation S6 0.306 0.113 _(ac)S(ph)KSES(ph)PKEPEQLR_
HNRNPA1 Ubiquitylation K8 -0.962 _SESPK(gl)EPEQLR_
HNRNPA1 Phosphorylation S22 0.705 _LFIGGLS(ph)FETTDESLR_
HNRNPA1 Phosphorylation S95 0.849 _EDS(ph)QRPGAHLTVK_
HNRNPA1 Ubiquitylation K105 0.268 0.130 _EDSQRPGAHLTVK(gl)K_
HNRNPA1 Ubiquitylation K106 0.268 _EDSQRPGAHLTVKK(gl)_
HNRNPA1 Ubiquitylation K183 1.234 _ALSK(gl)QEMASASSSQR_
HNRNPA1 Phosphorylation S337 -0.676 -0.603 _S(ph)SGPYGGGGQYFAK_
HNRNPA1 Phosphorylation S338 -0.603 _S(ph)SGPYGGGGQYFAK_
HNRNPA1 Ubiquitylation K350 -0.732 1.588 _SSGPYGGGGQYFAK(gl)PR_
HNRNPA1 Phosphorylation S360 0.578 _NQGGYGGS(ph)SSSSSYGSGR_
HNRNPA1 Phosphorylation S361 0.801 _NQGGYGGSS(ph)SSSSYGSGR_
HNRNPA1 Phosphorylation S368 0.872 1.197 _NQGGYGGSSSSSSYGS(ph)GR_
MATR3 Ubiquitylation K3 -0.669 -0.130 _(ac)SK(gl)SFQQSSLSR_
MATR3 Phosphorylation S9 1.062 1.758 _SFQQSS(ph)LSR_
MATR3 Phosphorylation T150 1.273 _RRT(ph)EEGPTLSYGR_
MATR3 Phosphorylation S164 -0.799 -0.754 _S(ph)ATREPPYR_
MATR3 Ubiquitylation K181 0.418 0.703 _DDWEEK(gl)R_
MATR3 Phosphorylation S188 0.552 0.352 _RDS(ph)FDDR_
MATR3 Phosphorylation S195 0.999 0.590 _RDSFDDRGPS(ph)LNPVLDYDHGSR_
MATR3 Phosphorylation S206 -0.408 2.048 _GPSLNPVLDYDHGS(ph)R_
MATR3 Phosphorylation S208 3.082 2.840 _S(ph)QESGYYDR_
MATR3 Phosphorylation S211 1.684 _DSFDDRGPSLNPVLDYDHGSRSQES(ph)GYYDR_
MATR3 Ubiquitylation K491 -0.193 0.356 _FDQK(gl)QELGR_
MATR3 Ubiquitylation K522 -1.136 -0.691 _LAEPYGK(gl)IK_
MATR3 Ubiquitylation K524 -0.770 _LAEPYGKIK(gl)_
MATR3 Ubiquitylation K554 -0.121 0.185 _EDAMAMVDHCLK(gl)K_
MATR3 Ubiquitylation K555 0.016 0.639 _K(gl)ALWFQGR_
MATR3 Ubiquitylation K565 0.765 _CVK(gl)VDLSEK_
MATR3 Ubiquitylation K571 0.335 _VDLSEK(gl)YK_
MATR3 Ubiquitylation K588 -0.137 0.306 _GIDLLK(gl)K_
MATR3 Ubiquitylation K589 0.306 _GIDLLK(gl)K_
MATR3 Phosphorylation S596 -0.031 0.457 _RS(ph)YSPDGK_
MATR3 Phosphorylation S598 0.251 0.233 _SYS(ph)PDGKESPSDK_
MATR3 Phosphorylation S604 1.224 1.629 _SYS(ph)PDGKES(ph)PSDK_
MATR3 Phosphorylation T612 2.910 2.961 _T(ph)DGSQKTESSTEGKEQEEK_
MATR3 Phosphorylation S615 2.286 2.251 _TDGS(ph)QKTESSTEGKEQEEK_
MATR3 Phosphorylation S621 2.639 1.672 _TDGSQKTESS(ph)TEGKEQEEK_
MATR3 Phosphorylation S814 -1.235 _NEENTEPGAESSENADDPNKDTSENADGQS(ph)DENKDDYTIPDEYR_
MATR3 Ubiquitylation K880 1.094 _LKK(gl)FLNK_
MATR3 Ubiquitylation K884 0.657 0.492 _FLNK(gl)LAEERR_
OPTN Ubiquitylation K448 -0.263 0.596 _QLQMDEMK(gl)QTIAK_
PFN1 Ubiquitylation K54 -0.190 0.319 _TFVNITPAEVGVLVGK(gl)DR_
PFN1 Ubiquitylation K70 0.186 0.451 _SSFYVNGLTLGGQK(gl)CSVIR_
PFN1 Ubiquitylation K91 -0.513 -0.205 _TK(gl)STGGAPTFNVTVTK_
PFN1 Ubiquitylation K105 0.309 -0.352 _STGGAPTFNVTVTK(gl)TDK_
PFN1 Ubiquitylation K108 0.414 -0.098 _TDK(gl)TLVLLMGK_
PFN1 Ubiquitylation K126 0.640 0.539 _EGVHGGLINK(gl)K_
PFN1 Ubiquitylation K127 0.582 0.353 _EGVHGGLINKK(gl)_
SOD1 Ubiquitylation K4 -0.329 _(ac)ATK(gl)AVCVLK_
SOD1 Ubiquitylation K10 0.211 0.582 _AVCVLK(gl)GDGPVQGIINFEQK_
SOD1 Ubiquitylation K24 -0.435 -0.086 _GDGPVQGIINFEQK(gl)ESNGPVK_
SOD1 Ubiquitylation K31 -0.109 0.332 _ESNGPVK(gl)VWGSIK_
SOD1 Phosphorylation S99 0.405 _HVGDLGNVTADKDGVADVS(ph)IEDSVISLSGDHCIIGR_
SOD1 Ubiquitylation K123 0.352 0.004 _TLVVHEK(gl)ADDLGK_
SOD1 Ubiquitylation K129 0.143 _ADDLGK(gl)GGNEESTK_
SOD1 Ubiquitylation K137 0.464 0.934 _ADDLGKGGNEESTK(gl)TGNAGSR_
SQSTM1 Ubiquitylation K13 0.150 0.302 _AYLLGK(gl)EDAAR_
SQSTM1 Phosphorylation S28 -0.721 _RFSFCCS(ph)PEPEAEAEAAAGPGPCER_
SQSTM1 Ubiquitylation K141 -0.915 _YK(gl)CSVCPDYDLCSVCEGK_
SQSTM1 Ubiquitylation K157 -0.852 -0.677 _CSVCPDYDLCSVCEGK(gl)GLHR_
SQSTM1 Phosphorylation T269 -0.681 -0.421 _LT(ph)PVS(ph)PESSSTEEK_
SQSTM1 Phosphorylation S272 0.171 0.044 _LTPVS(ph)PESSSTEEK_
SQSTM1 Phosphorylation S332 -0.007 _IALESEGRPEEQMESDNCS(ph)GGDDDWTHLSSK_
SQSTM1 Ubiquitylation K420 -1.122 -0.061 _LLQTK(gl)NYDIGAALDTIQYSK_
SQSTM1 Ubiquitylation K435 -1.352 -0.780 _NYDIGAALDTIQYSK(gl)HPPPL_
TARDBP Ubiquitylation K95 0.123 _KMDETDASSAVK(gl)VK_
TARDBP Ubiquitylation K145 0.090 _TGHSK(gl)GFGFVR_
TARDBP Ubiquitylation K160 0.720 _FTEYETQVK(gl)VMSQR_
TARDBP Ubiquitylation K176 -0.001 0.145 _WCDCK(gl)LPNSK_
TARDBP Ubiquitylation K181 -0.479 -0.804 _LPNSK(gl)QSQDEPLR_
TARDBP Ubiquitylation K263 0.619 _GISVHISNAEPK(gl)HNSNR_
VAPB Ubiquitylation K3 0.174 _(ac)AK(gl)VEQVLSLEPQHELK_
VAPB Ubiquitylation K118 -0.217 _EAKPEDLMDSK(gl)LR_
VAPB Ubiquitylation K147 0.150 0.167 _IISTTASK(gl)TETPIVSK_
VAPB Phosphorylation S158 2.164 2.536 _SLS(ph)SSLDDTEVKK_
VAPB Phosphorylation S160 0.543 0.936 _SLSSS(ph)LDDTEVKK_
VAPB Ubiquitylation K167 0.270 _SLSSSLDDTEVK(gl)K_
VAPB Ubiquitylation K168 0.270 _SLSSSLDDTEVK(gl)K_
VAPB Ubiquitylation K180 1.211 _LMEECK(gl)R_
VAPB Ubiquitylation K188 0.176 0.874 _LQGEMMK(gl)LSEENR_
VAPB Phosphorylation S214 0.747 1.178 _VAHSDKPGS(ph)TSTASFR_
VCP Phosphorylation S3 0.795 1.142 _(ac)AS(ph)GADSKGDDLSTAILK_
VCP Phosphorylation S7 0.312 0.941 _(ac)ASGADS(ph)KGDDLSTAILK_
VCP Ubiquitylation K8 -0.439 -0.154 _(ac)ASGADSK(gl)GDDLSTAILK_
VCP Ubiquitylation K18 -0.452 0.181 _GDDLSTAILK(gl)QK_
VCP Ubiquitylation K20 -0.512 0.529 _(ac)ASGADSKGDDLSTAILKQK(gl)_
VCP Ubiquitylation K60 0.678 0.493 _GDTVLLK(gl)GKK_
VCP Ubiquitylation K81 0.084 _EAVCIVLSDDTCSDEK(gl)IR_
VCP Ubiquitylation K109 -0.847 -0.260 _LGDVISIQPCPDVK(gl)YGK(gl)R_
VCP Ubiquitylation K112 -0.736 -0.276 _LGDVISIQPCPDVK(gl)YGK(gl)R_
VCP Ubiquitylation K148 -0.262 -0.087 _K(gl)GDIFLVR_
VCP Ubiquitylation K211 1.383 0.902 _K(gl)QLAQIK_
VCP Ubiquitylation K236 -0.526 -0.178 _AIGVK(gl)PPR_
VCP Ubiquitylation K251 -0.110 _GILLYGPPGTGK(gl)TLIAR_
VCP Ubiquitylation K336 0.522 _IVSQLLTLMDGLK(gl)QR_
VCP Ubiquitylation K386 1.339 0.706 _LEILQIHTK(gl)NM(ox)K_
VCP Ubiquitylation K389 0.568 1.195 _LEILQIHTKNMK(gl)_
VCP Ubiquitylation K505 0.377 0.794 _FLK(gl)FGMTPSK_
VCP Ubiquitylation K524 -0.528 _GVLFYGPPGCGK(gl)TLLAK_
VCP Ubiquitylation K529 -0.250 _GVLFYGPPGCGKTLLAK(gl)_
VCP Ubiquitylation K565 0.645 0.689 _EIFDK(gl)AR_
VCP Ubiquitylation K615 1.209 1.270 _VINQILTEMDGMSTKK(gl)_
VCP Ubiquitylation K651 -1.709 -0.719 _LDQLIYIPLPDEK(gl)SR_
VCP Ubiquitylation K658 0.362 0.711 _VAILK(gl)ANLR_
VCP Ubiquitylation K663 -0.839 _K(gl)SPVAKDVDLEFLAK_
VCP Ubiquitylation K668 -0.536 0.265 _SPVAK(gl)DVDLEFLAK_
VCP Ubiquitylation K696 1.574 1.691 _ACK(gl)LAIR_
VCP Ubiquitylation K754 0.510 0.939 _K(gl)YEMFAQTLQQSR_


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