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Query: VAPB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VAPB 2 4.074 1.440 -0.660 -2.551 0.014 0.056
VAPB 2 4.074 1.440 -0.660 0.042 0.495

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VAPB Phosphorylation S158 2.164 2.536 _SLS(ph)SSLDDTEVKK_
VAPB Ubiquitylation K180 1.211 _LMEECK(gl)R_
VAPB Phosphorylation S214 0.747 1.178 _VAHSDKPGS(ph)TSTASFR_
VAPB Phosphorylation S160 0.543 0.936 _SLSSS(ph)LDDTEVKK_
VAPB Ubiquitylation K188 0.176 0.874 _LQGEMMK(gl)LSEENR_
VAPB Ubiquitylation K167 0.270 _SLSSSLDDTEVK(gl)K_
VAPB Ubiquitylation K168 0.270 _SLSSSLDDTEVK(gl)K_
VAPB Ubiquitylation K147 0.150 0.167 _IISTTASK(gl)TETPIVSK_
VAPB Ubiquitylation K3 0.174 _(ac)AK(gl)VEQVLSLEPQHELK_
VAPB Ubiquitylation K118 -0.217 _EAKPEDLMDSK(gl)LR_

Background Information for VAPB:


Pubmed-VAPB »
Uniprot-VAPB »
Biogrid-VAPB »
ProteomicsDB-VAPB »

Tumorportal-VAPB »
COSMIC-VAPB »
GenomeRNAi-VAPB »
Genecards-VAPB


Protein-protein Interactions for VAPB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait ERBB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM82A2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM170A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VAPB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Vesicle-associated_membrane IPR016763 0.23
Category members MSP_dom IPR000535 0.04
Category members PapD-like IPR008962 0.02


Protein complexes (CORUM database) featuring VAPB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring VAPB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members GO Category GO:0048487 beta-tubulin binding Database 0.1
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0045070 positive regulation of viral genome replication Database 0.04
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_128 REACTOME_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_498 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS 0 0
Category members GO Category GO:0006665 sphingolipid metabolic process Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0030148 sphingolipid biosynthetic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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