bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SOD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SOD1 0 1.803 1.450 -1.250

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SOD1 Ubiquitylation K137 0.464 0.934 _ADDLGKGGNEESTK(gl)TGNAGSR_
SOD1 Ubiquitylation K10 0.211 0.582 _AVCVLK(gl)GDGPVQGIINFEQK_
SOD1 Phosphorylation S99 0.405 _HVGDLGNVTADKDGVADVS(ph)IEDSVISLSGDHCIIGR_
SOD1 Ubiquitylation K31 -0.109 0.332 _ESNGPVK(gl)VWGSIK_
SOD1 Ubiquitylation K123 0.352 0.004 _TLVVHEK(gl)ADDLGK_
SOD1 Ubiquitylation K24 -0.435 -0.086 _GDGPVQGIINFEQK(gl)ESNGPVK_
SOD1 Ubiquitylation K4 -0.329 _(ac)ATK(gl)AVCVLK_
SOD1 Ubiquitylation K129 0.143 _ADDLGK(gl)GGNEESTK_

Background Information for SOD1:


Pubmed-SOD1 »
Uniprot-SOD1 »
Biogrid-SOD1 »
ProteomicsDB-SOD1 »

Tumorportal-SOD1 »
COSMIC-SOD1 »
GenomeRNAi-SOD1 »
Genecards-SOD1


Protein-protein Interactions for SOD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APOL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SOD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SOD_Cu_Zn_dom IPR001424 0


Protein complexes (CORUM database) featuring SOD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SOD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051881 regulation of mitochondrial membrane potential Database 1.57
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0032287 peripheral nervous system myelin maintenance Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0000302 response to reactive oxygen species Database 0.35
Category members GO Category GO:0040014 regulation of multicellular organism growth Database 0.35
Category members GO Category GO:0002262 myeloid cell homeostasis Database 0.3
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0032930 positive regulation of superoxide anion generation Database 0.27
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0000303 response to superoxide Database 0.23
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0019226 transmission of nerve impulse Database 0.19
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_450 BIOCARTA_LONGEVITY_PATHWAY 0 0.13
Category members GO Category GO:0032314 regulation of Rac GTPase activity Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0048365 Rac GTPase binding Database 0.1
Category members GO Category GO:0008217 regulation of blood pressure Database 0.09
Category members GO Category GO:0008090 retrograde axon cargo transport Database 0.08
Category members GO Category GO:0042554 superoxide anion generation Database 0.05
Category members GO Category GO:0001819 positive regulation of cytokine production Database 0.05
Category members GO Category GO:0030346 protein phosphatase 2B binding Database 0.05
Category members GO Category GO:0060088 auditory receptor cell stereocilium organization Database 0.05
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0046620 regulation of organ growth Database 0.03
Category members GO Category GO:0045859 regulation of protein kinase activity Database 0.01
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_25 KEGG_PEROXISOME 0 0
Category members Pathway Pathway_384 BIOCARTA_FREE_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_883 KEGG_PRION_DISEASES 0 0
Category members Disease phenotype AMYOTROPHIC_LATERAL_SCLEROSIS_1 AMYOTROPHIC LATERAL SCLEROSIS 1 Database 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0001890 placenta development Database 0
Category members GO Category GO:0001895 retina homeostasis Database 0
Category members GO Category GO:0001975 response to amphetamine Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0004784 superoxide dismutase activity Database 0
Category members GO Category GO:0005507 copper ion binding Database 0
Category members GO Category GO:0005777 peroxisome Database 0
Category members GO Category GO:0006749 glutathione metabolic process Database 0
Category members GO Category GO:0006801 superoxide metabolic process Database 0
Category members GO Category GO:0006879 cellular iron ion homeostasis Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007566 embryo implantation Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0008089 anterograde axon cargo transport Database 0
Category members GO Category GO:0009408 response to heat Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0019430 removal of superoxide radicals Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031667 response to nutrient levels Database 0
Category members GO Category GO:0032839 dendrite cytoplasm Database 0
Category members GO Category GO:0033081 regulation of T cell differentiation in thymus Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045541 negative regulation of cholesterol biosynthetic process Database 0
Category members GO Category GO:0046688 response to copper ion Database 0
Category members GO Category GO:0046716 muscle cell cellular homeostasis Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0050665 hydrogen peroxide biosynthetic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0060047 heart contraction Database 0
Category members GO Category GO:0060052 neurofilament cytoskeleton organization Database 0
Category members GO Category GO:0060087 relaxation of vascular smooth muscle Database 0


.

© Copyright Svejstrup Laboratory 2015