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Query: TARDBP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TARDBP 0 1.279 -1.050 1.160 -0.359 -1.276 -0.495 -0.408 0.021

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TARDBP Ubiquitylation K176 -0.001 0.145 _WCDCK(gl)LPNSK_
TARDBP Ubiquitylation K181 -0.479 -0.804 _LPNSK(gl)QSQDEPLR_
TARDBP Ubiquitylation K95 0.123 _KMDETDASSAVK(gl)VK_
TARDBP Ubiquitylation K145 0.090 _TGHSK(gl)GFGFVR_
TARDBP Ubiquitylation K160 0.720 _FTEYETQVK(gl)VMSQR_
TARDBP Ubiquitylation K263 0.619 _GISVHISNAEPK(gl)HNSNR_

Background Information for TARDBP:


Pubmed-TARDBP »
Uniprot-TARDBP »
Biogrid-TARDBP »
ProteomicsDB-TARDBP »

Tumorportal-TARDBP »
COSMIC-TARDBP »
GenomeRNAi-TARDBP »
Genecards-TARDBP


Protein-protein Interactions for TARDBP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HNRNPF Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait IP6K3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TARDBP Cat. description Hein, Mann, Cell 2015
Category members IP bait GNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TARDBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TARDBP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34


Protein complexes (CORUM database) featuring TARDBP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1332 Large Drosha complex Database 0.08


Categories featuring TARDBP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0003730 mRNA 3'-UTR binding Database 0.24
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members GO Category GO:0008219 cell death Database 0.08
Category members Disease phenotype Frontotemporal_dementia_with_motor_neuron_disease Frontotemporal dementia with motor neuron disease Database 0
Category members GO Category GO:0070935 3'-UTR-mediated mRNA stabilization Database 0


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