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Query: ERBB4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERBB4 0 0.421

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ERBB4 Ubiquitylation K745 -0.474 0.342 _GIWVPEGETVK(gl)IPVAIK_
ERBB4 Ubiquitylation K854 -0.859 _NVLVK(gl)SPNHVK_
ERBB4 Ubiquitylation K714 0.078 _ILK(gl)ETELKR_

Background Information for ERBB4:


Pubmed-ERBB4 »
Uniprot-ERBB4 »
Biogrid-ERBB4 »
ProteomicsDB-ERBB4 »

Tumorportal-ERBB4 »
COSMIC-ERBB4 »
GenomeRNAi-ERBB4 »
Genecards-ERBB4


Protein-protein Interactions for ERBB4
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in ERBB4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members EGF_rcpt_L IPR000494 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Furin-like_Cys-rich_dom IPR006211 0
Category members Furin_repeat IPR006212 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members Tyr_kinase_EGF/ERB/XmrK_rcpt IPR016245 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring ERBB4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ERBB4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity Database 0.1
Category members GO Category GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein Database 0.1
Category members GO Category GO:0060045 positive regulation of cardiac muscle cell proliferation Database 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Pathway Pathway_639 BIOCARTA_HER2_PATHWAY 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1068 PID_ERBB_NETWORK_PATHWAY 0 0
Category members Pathway Pathway_1070 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 0 0
Category members Pathway Pathway_1112 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0001755 neural crest cell migration Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0004716 receptor signaling protein tyrosine kinase activity Database 0
Category members GO Category GO:0005154 epidermal growth factor receptor binding Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009880 embryonic pattern specification Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0021551 central nervous system morphogenesis Database 0
Category members GO Category GO:0021889 olfactory bulb interneuron differentiation Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043653 mitochondrial fragmentation involved in apoptotic process Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0060644 mammary gland epithelial cell differentiation Database 0
Category members GO Category GO:0060749 mammary gland alveolus development Database 0


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