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transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
EPHA7 2 2.050 -0.990 0.221
EPHA7 2 2.050 -0.990
INSR 2 -0.850 0.830 1.143 0.785
IGF1R 1 -0.490 0.750 1.476 0.714
PTPRG 1 0.610 -0.500 1.092 0.353
FIP1L1 1 -1.930 3.940 0.293 -0.487 0.231 -0.419 0.354
LYN 1 -1.790 3.770
LYN 1 -1.790 3.770
FLT4 0 0.940 -0.560
PIK3CB 0 -1.390 2.350
PIK3CB 0 -0.710 1.450
FLT1 0 -1.240 1.900
MET 0 -0.010 -0.330
RAPGEF1 0 1.620 -0.780
CD3EAP 0 -0.100 0.105
KDR 0 0.860 -0.680
EPHB2 0 -0.630 0.780 0.221
EPHB2 0 -0.630 0.780
ABI1 0 0.853 0.389
ERBB2 0 -1.310 1.360
EPHA2 0 1.330 -0.460 0.221
EPHA5 0 -0.280 0.790
EGFR 0 -0.580 0.520 0.513 0.090
EPHB1 0 -0.220 0.000 0.221
EPHB1 0 -0.220 0.000 -0.042
EPHB1 0 -0.220 0.000
ROR2 0 0.180 -0.350
ERBB4 0
ERBB4 0
EPHB3 0 0.800 -0.380 0.221
EPHB3 0 0.800 -0.380
EPHB4 0 1.130 -1.030
MPZL1 0 0.900 -1.140
MPZL1 0 1.230 -0.540
MPZL1 0 1.660 -0.850

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ABI1 Phosphorylation T179 -1.186 _TNPPT(ph)QKPPSPPMSGR_
ABI1 Phosphorylation S184 -1.237 -1.395 _TNPPTQKPPS(ph)PPMSGR_
ABI1 Phosphorylation T230 0.423 0.203 _T(ph)ASLNQRPR_
ABI1 Phosphorylation S232 0.057 0.186 _TAS(ph)LNQRPR_
ABI1 Phosphorylation S324 1.188 _HNS(ph)TTSSTSSGGYRR_
CD3EAP Phosphorylation S126 -2.147 _ILEGPQQSLS(ph)GSPLQPIPASPPPQIPPGLRPR_
CD3EAP Phosphorylation S128 -2.441 _ILEGPQQSLSGS(ph)PLQPIPASPPPQIPPGLRPR_
CD3EAP Phosphorylation S136 -1.636 _ILEGPQQSLSGSPLQPIPAS(ph)PPPQIPPGLRPR_
CD3EAP Phosphorylation T171 -0.767 _SALAPNLLT(ph)SGK_
CD3EAP Phosphorylation S172 -0.767 _SALAPNLLT(ph)SGK_
CD3EAP Phosphorylation S285 -1.326 -0.880 _QEQINTEPLEDTVLS(ph)PTK_
CD3EAP Phosphorylation S490 -1.234 _MPETVPQEEMPGPPLNSES(ph)GEEAPTGR_
EGFR Phosphorylation T693 0.486 -0.139 _ELVEPLT(ph)PSGEAPNQALLR_
EGFR Phosphorylation S991 -0.041 _MHLPS(ph)PTDSNFYR_
EPHA2 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHA2 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHA2 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHA2 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHA2 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHA2 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHA5 Ubiquitylation K657 0.533 _LKLPGK(gl)R_
EPHA7 Ubiquitylation K180 0.633 _EIGPLSKK(gl)_
EPHA7 Ubiquitylation K272 0.520 _AGYQQK(gl)GDTCEPCGR_
EPHA7 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHA7 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHA7 Ubiquitylation K606 -0.162 _FPGTK(gl)TYIDPETYEDPNR_
EPHA7 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHA7 Ubiquitylation K634 0.732 1.340 _ELDASCIK(gl)IER_
EPHA7 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHA7 Ubiquitylation K657 0.533 _LKLPGK(gl)R_
EPHA7 Ubiquitylation K665 3.196 _DVAVAIK(gl)TLK_
EPHA7 Ubiquitylation K797 -1.229 -0.459 _VIEDDPEAVYTTTGGK(gl)IPVR_
EPHA7 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHA7 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHA7 Phosphorylation S912 -0.413 _TPLGTCSRPIS(ph)PLLDQNTPDFTTFCSVGEWLQAIK_
EPHB1 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHB1 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHB1 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHB1 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHB1 Ubiquitylation K657 0.533 _LKLPGK(gl)R_
EPHB1 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHB1 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHB2 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHB2 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHB2 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHB2 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHB2 Phosphorylation S776 -0.147 -0.171 _FLEDDTS(ph)DPTYTSALGGK_
EPHB2 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHB2 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHB3 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHB3 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHB3 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHB3 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHB3 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHB3 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHB3 Ubiquitylation K960 0.133 _IGVTLAGHQKK(gl)_
EPHB4 Ubiquitylation K885 -1.394 _NPASLK(gl)IVAR_
EPHB4 Ubiquitylation K960 0.133 _IGVTLAGHQKK(gl)_
ERBB2 Ubiquitylation K200 -2.073 _ACHPCSPMCK(gl)GSR_
ERBB2 Ubiquitylation K369 -0.742 _AVTSANIQEFAGCKK(gl)_
ERBB2 Ubiquitylation K747 -0.505 -0.019 _GIWIPDGENVK(gl)IPVAIK_
ERBB2 Ubiquitylation K854 -0.859 _NVLVK(gl)SPNHVK_
ERBB2 Phosphorylation S1054 -0.476 -0.706 _S(ph)GGGDLTLGLEPSEEEAPR_
ERBB4 Ubiquitylation K714 0.078 _ILK(gl)ETELKR_
ERBB4 Ubiquitylation K745 -0.474 0.342 _GIWVPEGETVK(gl)IPVAIK_
ERBB4 Ubiquitylation K854 -0.859 _NVLVK(gl)SPNHVK_
FIP1L1 Ubiquitylation K123 -1.286 _TGAPQYGSYGTAPVNLNIK(gl)TGGR_
FIP1L1 Phosphorylation S259 -1.364 -0.698 _AEFTS(ph)PPSLFK_
FIP1L1 Phosphorylation S492 0.040 0.085 _DHS(ph)PTPSVFNSDEER_
FIP1L1 Phosphorylation T494 0.134 0.020 _DHSPT(ph)PSVFNSDEER_
FLT1 Ubiquitylation K953 -1.081 _MEPGLEQGK(gl)KPR_
FLT4 Ubiquitylation K987 -0.270 _FSK(gl)TEGGAR_
FLT4 Ubiquitylation K1064 -1.119 _DIYK(gl)DPDYVR_
IGF1R Ubiquitylation K47 1.146 _NDYQQLK(gl)R_
IGF1R Ubiquitylation K1033 5.779 _VAIK(gl)TVNEAASMR_
IGF1R Ubiquitylation K1168 0.191 _K(gl)GGKGLLPVR_
IGF1R Ubiquitylation K1171 0.232 _GGK(gl)GLLPVR_
INSR Ubiquitylation K1022 -0.603 _EK(gl)ITLLR_
INSR Ubiquitylation K1047 0.305 0.711 _DIIK(gl)GEAETR_
INSR Ubiquitylation K1057 0.482 0.484 _VAVK(gl)TVNESASLR_
INSR Ubiquitylation K1352 1.606 2.754 _DGGSSLGFK(gl)R_
KDR Ubiquitylation K1064 -1.119 _DIYK(gl)DPDYVR_
LYN Ubiquitylation K20 -0.592 _GKDSLSDDGVDLK(gl)TQPVR_
LYN Ubiquitylation K40 0.100 _DPTSNK(gl)QQRPVPESQLLPGQR_
LYN Phosphorylation S104 0.944 0.841 _DSLS(ph)DDGVDLK_
LYN Ubiquitylation K213 0.441 _HYQK(gl)QADGLCR_
LYN Ubiquitylation K477 -0.191 _VENCPDELYDIMK(gl)MCWK_
MET Ubiquitylation K962 0.146 _QIK(gl)DLGSELVR_
MET Phosphorylation S988 0.064 _S(ph)VSPTTEM(ox)VSNESVDYR_
MET Phosphorylation S990 0.192 -0.105 _SVS(ph)PTTEM(ox)VSNESVDYR_
MET Phosphorylation T992 0.501 -0.048 _SVSPT(ph)TEMVSNESVDYR_
MET Phosphorylation S997 0.285 _S(ph)VSPTTEMVS(ph)NESVDYR_
MPZL1 Phosphorylation S204 0.041 0.806 _DYTGCS(ph)TSESLSPVK_
MPZL1 Phosphorylation T205 0.091 0.306 _DYTGCST(ph)SESLSPVK_
MPZL1 Phosphorylation S206 0.581 _DYTGCSTS(ph)ESLSPVK_
MPZL1 Phosphorylation S208 -0.484 _DYTGCSTSES(ph)LSPVK_
MPZL1 Phosphorylation S210 0.120 0.160 _DYTGCSTSESLS(ph)PVK_
MPZL1 Ubiquitylation K213 -0.850 -1.043 _DYTGCSTSESLSPVK(gl)QAPR_
MPZL1 Ubiquitylation K218 -0.070 0.012 _K(gl)SPSDTEGLVK_
MPZL1 Phosphorylation S219 0.202 0.573 _KS(ph)PSDTEGLVK_
MPZL1 Phosphorylation S221 1.343 _KSPS(ph)DTEGLVK_
MPZL1 Phosphorylation Y263 0.402 _SESVVY(ph)ADIR_
PIK3CB Ubiquitylation K1044 0.990 _SEEEALKQFKQK(gl)_
PTPRG Ubiquitylation K899 1.705 _LRPLPGK(gl)DSK_
PTPRG Ubiquitylation K1155 0.544 _QFK(gl)LVTQCNAK_
PTPRG Phosphorylation S1182 0.408 0.434 _NRNS(ph)SVVPSER_
RAPGEF1 Phosphorylation S377 0.629 _LSKS(ph)DEQLSSLDR_
ROR2 Ubiquitylation K97 0.598 _WLK(gl)NDAPVVQEPR_
ROR2 Ubiquitylation K510 -0.960 _TLK(gl)DKAEGPLREEFR_
ROR2 Ubiquitylation K512 0.282 _DK(gl)AEGPLREEFR_


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