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Query: RAPGEF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAPGEF1 0 0.629 1.620 -0.780

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAPGEF1 Phosphorylation S377 0.629 _LSKS(ph)DEQLSSLDR_

Background Information for RAPGEF1:


Pubmed-RAPGEF1 »
Uniprot-RAPGEF1 »
Biogrid-RAPGEF1 »
ProteomicsDB-RAPGEF1 »

Tumorportal-RAPGEF1 »
COSMIC-RAPGEF1 »
GenomeRNAi-RAPGEF1 »
Genecards-RAPGEF1


Protein-protein Interactions for RAPGEF1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in RAPGEF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ras-like_Gua-exchang_fac_N IPR000651 0
Category members RASGEF_cat_dom IPR001895 0
Category members Ras_GEF_dom IPR023578 0


Protein complexes (CORUM database) featuring RAPGEF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5444 CRKII-C3G complex Database 0.11
Category members Corum 2476 CRKL-PDGFRA-CRK-RAPGEF1 complex Database 0


Categories featuring RAPGEF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_688 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 0 0.47
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_1004 REACTOME_ARMS_MEDIATED_ACTIVATION 0 0.4
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_694 REACTOME_SIGNALLING_TO_ERKS 0 0.13
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members GO Category GO:0061028 establishment of endothelial barrier Database 0.06
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_576 REACTOME_REGULATION_OF_SIGNALING_BY_CBL 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0017034 Rap guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0032486 Rap protein signal transduction Database 0
Category members GO Category GO:0032854 positive regulation of Rap GTPase activity Database 0
Category members GO Category GO:0038180 nerve growth factor signaling pathway Database 0
Category members GO Category GO:0048008 platelet-derived growth factor receptor signaling pathway Database 0
Category members GO Category GO:0071320 cellular response to cAMP Database 0


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