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Query: EPHB2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EPHB2 0 1.847 -0.630 0.780
EPHB2 0 1.847 -0.630 0.780 0.221

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EPHB2 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHB2 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHB2 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHB2 Phosphorylation S776 -0.147 -0.171 _FLEDDTS(ph)DPTYTSALGGK_
EPHB2 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHB2 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHB2 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_

Background Information for EPHB2:


Pubmed-EPHB2 »
Uniprot-EPHB2 »
Biogrid-EPHB2 »
ProteomicsDB-EPHB2 »

Tumorportal-EPHB2 »
COSMIC-EPHB2 »
GenomeRNAi-EPHB2 »
Genecards-EPHB2


Protein-protein Interactions for EPHB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EFNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EPHB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ephrin_rcpt_lig-bd_dom IPR001090 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SAM IPR001660 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Galactose-bd-like IPR008979 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members SAM_2 IPR011510 0
Category members Tyr-kin_ephrin_A/B_rcpt-like IPR011641 0
Category members SAM/pointed IPR013761 0
Category members Tyr_kinase_ephrin_rcpt IPR016257 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members SAM_type1 IPR021129 0


Protein complexes (CORUM database) featuring EPHB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EPHB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0016310 phosphorylation Database 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0021631 optic nerve morphogenesis Database 0.13
Category members Pathway Pathway_735 ST_MYOCYTE_AD_PATHWAY 0 0.09
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members Disease phenotype Familial_prostate_cancer Familial prostate cancer Database 0.07
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_517 ST_GRANULE_CELL_SURVIVAL_PATHWAY 0 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_725 ST_GA12_PATHWAY 0 0
Category members Disease phenotype PROSTATE_CANCER PROSTATE CANCER Database 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001655 urogenital system development Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0005003 ephrin receptor activity Database 0
Category members GO Category GO:0005005 transmembrane-ephrin receptor activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007413 axonal fasciculation Database 0
Category members GO Category GO:0007612 learning Database 0
Category members GO Category GO:0008046 axon guidance receptor activity Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0021952 central nervous system projection neuron axonogenesis Database 0
Category members GO Category GO:0022038 corpus callosum development Database 0
Category members GO Category GO:0031290 retinal ganglion cell axon guidance Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048013 ephrin receptor signaling pathway Database 0
Category members GO Category GO:0048168 regulation of neuronal synaptic plasticity Database 0
Category members GO Category GO:0048170 positive regulation of long-term neuronal synaptic plasticity Database 0
Category members GO Category GO:0048593 camera-type eye morphogenesis Database 0
Category members GO Category GO:0050770 regulation of axonogenesis Database 0
Category members GO Category GO:0050771 negative regulation of axonogenesis Database 0
Category members GO Category GO:0050878 regulation of body fluid levels Database 0
Category members GO Category GO:0051965 positive regulation of synapse assembly Database 0
Category members GO Category GO:0060996 dendritic spine development Database 0
Category members GO Category GO:0060997 dendritic spine morphogenesis Database 0


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