bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: FLT4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FLT4 0 -0.270 0.940 -0.560

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FLT4 Ubiquitylation K987 -0.270 _FSK(gl)TEGGAR_
FLT4 Ubiquitylation K1064 -1.119 _DIYK(gl)DPDYVR_

Background Information for FLT4:


Pubmed-FLT4 »
Uniprot-FLT4 »
Biogrid-FLT4 »
ProteomicsDB-FLT4 »

Tumorportal-FLT4 »
COSMIC-FLT4 »
GenomeRNAi-FLT4 »
Genecards-FLT4


Protein-protein Interactions for FLT4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C12orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPY2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FLT4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Ig_sub2 IPR003598 0.21
Category members Ig_I-set IPR013098 0.13
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring FLT4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5740 NRP2-VEGFR3 complex Database 0


Categories featuring FLT4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0001944 vasculature development Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0002040 sprouting angiogenesis Database 0.12
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0035924 cellular response to vascular endothelial growth factor stimulus Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Disease phenotype Milroy_Disease Milroy Disease Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1222 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS 0 0
Category members Pathway Pathway_1223 PID_VEGF_VEGFR_PATHWAY 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Disease phenotype HEMANGIOMA_CAPILLARY_INFANTILE HEMANGIOMA CAPILLARY INFANTILE Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0001945 lymph vessel development Database 0
Category members GO Category GO:0001946 lymphangiogenesis Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0005021 vascular endothelial growth factor-activated receptor activity Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010575 positive regulation vascular endothelial growth factor production Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0019838 growth factor binding Database 0
Category members GO Category GO:0038084 vascular endothelial growth factor signaling pathway Database 0
Category members GO Category GO:0046330 positive regulation of JNK cascade Database 0
Category members GO Category GO:0048010 vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048514 blood vessel morphogenesis Database 0


.

© Copyright Svejstrup Laboratory 2015