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Query: EPHB4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EPHB4 0 0.133 1.130 -1.030

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EPHB4 Ubiquitylation K885 -1.394 _NPASLK(gl)IVAR_
EPHB4 Ubiquitylation K960 0.133 _IGVTLAGHQKK(gl)_

Background Information for EPHB4:


Pubmed-EPHB4 »
Uniprot-EPHB4 »
Biogrid-EPHB4 »
ProteomicsDB-EPHB4 »

Tumorportal-EPHB4 »
COSMIC-EPHB4 »
GenomeRNAi-EPHB4 »
Genecards-EPHB4


Protein-protein Interactions for EPHB4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait SKP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZSCAN5A Cat. description Hein, Mann, Cell 2015
Category members IP bait ADPGK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EFNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GABRE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DRA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRIQ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MME Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHA12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EPHB4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ephrin_rcpt_lig-bd_dom IPR001090 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SAM IPR001660 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Galactose-bd-like IPR008979 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members SAM_2 IPR011510 0
Category members Tyr-kin_ephrin_A/B_rcpt-like IPR011641 0
Category members SAM/pointed IPR013761 0
Category members Tyr_kinase_ephrin_rcpt IPR016257 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members SAM_type1 IPR021129 0


Protein complexes (CORUM database) featuring EPHB4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EPHB4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0002042 cell migration involved in sprouting angiogenesis Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0005003 ephrin receptor activity Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0048013 ephrin receptor signaling pathway Database 0


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