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Query: INSR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
INSR 2 7.117 -0.850 0.830 1.143 0.785

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
INSR Ubiquitylation K1352 1.606 2.754 _DGGSSLGFK(gl)R_
INSR Ubiquitylation K1047 0.305 0.711 _DIIK(gl)GEAETR_
INSR Ubiquitylation K1057 0.482 0.484 _VAVK(gl)TVNESASLR_
INSR Ubiquitylation K1022 -0.603 _EK(gl)ITLLR_

Background Information for INSR:


Pubmed-INSR »
Uniprot-INSR »
Biogrid-INSR »
ProteomicsDB-INSR »

Tumorportal-INSR »
COSMIC-INSR »
GenomeRNAi-INSR »
Genecards-INSR


Protein-protein Interactions for INSR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait INSR Cat. description Hein, Mann, Cell 2015
Category members IP bait CLEC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNASE1L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PON2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPRK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UNC5CL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in INSR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19
Category members Tyr_kinase_insulin-like_rcpt IPR016246 0.13
Category members Kinase-like_dom IPR011009 0.03
Category members EGF_rcpt_L IPR000494 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Furin-like_Cys-rich_dom IPR006211 0
Category members Furin_repeat IPR006212 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring INSR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1093 SNX complex (SNX1a, SNX2, SNX4, INSR) Database 0.05
Category members Corum 2577 Sam68-p85 P13K-IRS-1-IR signaling complex Database 0.04


Categories featuring INSR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0045429 positive regulation of nitric oxide biosynthetic process Database 0.06
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0051290 protein heterotetramerization Database 0.05
Category members Disease phenotype DIABETES_MELLITUS_NONINSULIN-DEPENDENT DIABETES MELLITUS NONINSULIN-DEPENDENT Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0043559 insulin binding Database 0.04
Category members GO Category GO:0043560 insulin receptor substrate binding Database 0.03
Category members GO Category GO:0051425 PTB domain binding Database 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1058 REACTOME_SIGNAL_ATTENUATION 0 0
Category members Pathway Pathway_1108 REACTOME_SHC_RELATED_EVENTS 0 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_189 REACTOME_INSULIN_RECEPTOR_RECYCLING 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0004716 receptor signaling protein tyrosine kinase activity Database 0
Category members GO Category GO:0005159 insulin-like growth factor receptor binding Database 0
Category members GO Category GO:0005899 insulin receptor complex Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0019087 transformation of host cell by virus Database 0
Category members GO Category GO:0023014 signal transduction by phosphorylation Database 0
Category members GO Category GO:0030238 male sex determination Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031017 exocrine pancreas development Database 0
Category members GO Category GO:0031994 insulin-like growth factor I binding Database 0
Category members GO Category GO:0031995 insulin-like growth factor II binding Database 0
Category members GO Category GO:0032147 activation of protein kinase activity Database 0
Category members GO Category GO:0032148 activation of protein kinase B activity Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0045725 positive regulation of glycogen biosynthetic process Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0045821 positive regulation of glycolysis Database 0
Category members GO Category GO:0045840 positive regulation of mitosis Database 0
Category members GO Category GO:0045995 regulation of embryonic development Database 0
Category members GO Category GO:0046326 positive regulation of glucose import Database 0
Category members GO Category GO:0048639 positive regulation of developmental growth Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060267 positive regulation of respiratory burst Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0


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