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Query: EGFR

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EGFR 0 1.568 -0.580 0.520 0.513 0.090

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EGFR Phosphorylation S991 -0.041 _MHLPS(ph)PTDSNFYR_
EGFR Phosphorylation T693 0.486 -0.139 _ELVEPLT(ph)PSGEAPNQALLR_

Background Information for EGFR:


Pubmed-EGFR »
Uniprot-EGFR »
Biogrid-EGFR »
ProteomicsDB-EGFR »

Tumorportal-EGFR »
COSMIC-EGFR »
GenomeRNAi-EGFR »
Genecards-EGFR


Protein-protein Interactions for EGFR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PON2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPRK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EGFR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members EGF_rcpt_L IPR000494 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Furin-like_Cys-rich_dom IPR006211 0
Category members Furin_repeat IPR006212 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members Tyr_kinase_EGF/ERB/XmrK_rcpt IPR016245 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring EGFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 6036 PARK2-EPS15-EGFR Database 0.05
Category members Corum 1095 SNX complex (SNX1a, SNX2, SNX4, EGFR) Database 0.05
Category members Corum 1185 EGFR-containing signaling complex Database 0
Category members Corum 2369 ITGAV-ITGB3-EGFR complex Database 0
Category members Corum 2453 Multiprotein complex (monoubiquitination) Database 0
Category members Corum 2454 CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated Database 0
Category members Corum 2542 EGFR-CBL-GRB2 complex Database 0
Category members Corum 3678 RIN1-STAM2-EGFR complex, EGF stimulated Database 0
Category members Corum 5171 SH3KBP1-CBLB-EGFR complex Database 0


Categories featuring EGFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_583 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 0 0.68
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0042743 hydrogen peroxide metabolic process Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0030235 nitric-oxide synthase regulator activity Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0032930 positive regulation of superoxide anion generation Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0033590 response to cobalamin Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0030122 AP-2 adaptor complex Database 0.19
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members Disease phenotype Giant_cell_glioblastoma Giant cell glioblastoma Database 0.14
Category members Disease phenotype Gliosarcoma Gliosarcoma Database 0.14
Category members Pathway Pathway_1067 BIOCARTA_CBL_PATHWAY 0 0.14
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype LUNG_CANCER LUNG CANCER Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_947 BIOCARTA_EGFR_SMRTE_PATHWAY 0 0.09
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members GO Category GO:0004709 MAP kinase kinase kinase activity Database 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0050729 positive regulation of inflammatory response Database 0.08
Category members GO Category GO:0045429 positive regulation of nitric oxide biosynthetic process Database 0.06
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0035413 positive regulation of catenin import into nucleus Database 0.02
Category members Pathway Pathway_617 BIOCARTA_TFF_PATHWAY 0 0.02
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_639 BIOCARTA_HER2_PATHWAY 0 0.01
Category members GO Category GO:0045930 negative regulation of mitotic cell cycle Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0070141 response to UV-A Database 0.01
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1066 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 0 0
Category members Pathway Pathway_1068 PID_ERBB_NETWORK_PATHWAY 0 0
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_1070 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 0 0
Category members Pathway Pathway_1071 BIOCARTA_SPRY_PATHWAY 0 0
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_1073 KEGG_DORSO_VENTRAL_AXIS_FORMATION 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_691 BIOCARTA_CARDIACEGF_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0004716 receptor signaling protein tyrosine kinase activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005006 epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005976 polysaccharide metabolic process Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0006970 response to osmotic stress Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0007435 salivary gland morphogenesis Database 0
Category members GO Category GO:0007611 learning or memory Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008544 epidermis development Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0010960 magnesium ion homeostasis Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016101 diterpenoid metabolic process Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0021795 cerebral cortex cell migration Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0033594 response to hydroxyisoflavone Database 0
Category members GO Category GO:0033993 response to lipid Database 0
Category members GO Category GO:0042177 negative regulation of protein catabolic process Database 0
Category members GO Category GO:0042698 ovulation cycle Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0043586 tongue development Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0045907 positive regulation of vasoconstriction Database 0
Category members GO Category GO:0045909 positive regulation of vasodilation Database 0
Category members GO Category GO:0048143 astrocyte activation Database 0
Category members GO Category GO:0048408 epidermal growth factor binding Database 0
Category members GO Category GO:0048546 digestive tract morphogenesis Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0050730 regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050999 regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051205 protein insertion into membrane Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0051968 positive regulation of synaptic transmission, glutamatergic Database 0
Category members GO Category GO:0060571 morphogenesis of an epithelial fold Database 0
Category members GO Category GO:0070435 Shc-EGFR complex Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071364 cellular response to epidermal growth factor stimulus Database 0
Category members GO Category GO:0071392 cellular response to estradiol stimulus Database 0


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