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Query: ABI1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ABI1 0 2.853 0.853 0.389

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ABI1 Phosphorylation S324 1.188 _HNS(ph)TTSSTSSGGYRR_
ABI1 Phosphorylation T230 0.423 0.203 _T(ph)ASLNQRPR_
ABI1 Phosphorylation S232 0.057 0.186 _TAS(ph)LNQRPR_
ABI1 Phosphorylation T179 -1.186 _TNPPT(ph)QKPPSPPMSGR_
ABI1 Phosphorylation S184 -1.237 -1.395 _TNPPTQKPPS(ph)PPMSGR_

Background Information for ABI1:


Pubmed-ABI1 »
Uniprot-ABI1 »
Biogrid-ABI1 »
ProteomicsDB-ABI1 »

Tumorportal-ABI1 »
COSMIC-ABI1 »
GenomeRNAi-ABI1 »
Genecards-ABI1


Protein-protein Interactions for ABI1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ABI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAIAP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2E2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SASS6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ABI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AMZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BAIAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CGB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HOMER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKBIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LHX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NHSL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIMM50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBXN11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VASP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WASF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF511 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ABI1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members T_SNARE_dom IPR000727 0.54
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0
Category members Abl-interactor_HHR_dom IPR012849 0


Protein complexes (CORUM database) featuring ABI1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2297 ABI1-WASL complex Database 0.15
Category members Corum 186 Wave-2 complex Database 0.08
Category members Corum 2294 ABI1-WASF2 complex Database 0


Categories featuring ABI1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0008154 actin polymerization or depolymerization Database 0.47
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0061098 positive regulation of protein tyrosine kinase activity Database 0.04
Category members GO Category GO:0035855 megakaryocyte development Database 0.02
Category members Pathway Pathway_1024 PID_INTEGRIN_A4B1_PATHWAY 0 0
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0009987 cellular process Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030296 protein tyrosine kinase activator activity Database 0


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