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Query: KDR

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KDR 0 -1.119 0.860 -0.680

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KDR Ubiquitylation K1064 -1.119 _DIYK(gl)DPDYVR_

Background Information for KDR:


Pubmed-KDR »
Uniprot-KDR »
Biogrid-KDR »
ProteomicsDB-KDR »

Tumorportal-KDR »
COSMIC-KDR »
GenomeRNAi-KDR »
Genecards-KDR


Protein-protein Interactions for KDR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KDR Cat. description Hein, Mann, Cell 2015


Protein Domains in KDR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_sub2 IPR003598 0.21
Category members Ig_I-set IPR013098 0.13
Category members Ig_V-set IPR013106 0.09
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members CD80_C2-set IPR013162 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring KDR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4062 NRP1-VEGFR2-VEGF(165) complex Database 0
Category members Corum 5696 VEGFA(165)-KDR-NRP1 complex Database 0
Category members Corum 5698 VEGFA(165)-VEGFR2-NRP1 complex Database 0
Category members Corum 5772 ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex Database 0


Categories featuring KDR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0035162 embryonic hemopoiesis Database 0.17
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0035924 cellular response to vascular endothelial growth factor stimulus Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0038083 peptidyl-tyrosine autophosphorylation Database 0.03
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process Database 0.01
Category members GO Category GO:0002042 cell migration involved in sprouting angiogenesis Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_1222 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS 0 0
Category members Pathway Pathway_1223 PID_VEGF_VEGFR_PATHWAY 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_683 PID_S1P_S1P1_PATHWAY 0 0
Category members Pathway Pathway_740 PID_INTEGRIN3_PATHWAY 0 0
Category members Disease phenotype Familial_capillary_hemangioma Familial capillary hemangioma Database 0
Category members Disease phenotype HEMANGIOMA_CAPILLARY_INFANTILE HEMANGIOMA CAPILLARY INFANTILE Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0001945 lymph vessel development Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0003158 endothelium development Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0004716 receptor signaling protein tyrosine kinase activity Database 0
Category members GO Category GO:0005021 vascular endothelial growth factor-activated receptor activity Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0019838 growth factor binding Database 0
Category members GO Category GO:0023014 signal transduction by phosphorylation Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0035584 calcium-mediated signaling using intracellular calcium source Database 0
Category members GO Category GO:0038085 vascular endothelial growth factor binding Database 0
Category members GO Category GO:0043129 surfactant homeostasis Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0045446 endothelial cell differentiation Database 0
Category members GO Category GO:0048010 vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048469 cell maturation Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0
Category members GO Category GO:0050927 positive regulation of positive chemotaxis Database 0
Category members GO Category GO:0051879 Hsp90 protein binding Database 0
Category members GO Category GO:0051894 positive regulation of focal adhesion assembly Database 0
Category members GO Category GO:0055074 calcium ion homeostasis Database 0


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