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Query: IGF1R

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IGF1R 1 9.865 -0.490 0.750 1.476 0.714

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IGF1R Ubiquitylation K47 1.146 _NDYQQLK(gl)R_
IGF1R Ubiquitylation K1033 5.779 _VAIK(gl)TVNEAASMR_
IGF1R Ubiquitylation K1168 0.191 _K(gl)GGKGLLPVR_
IGF1R Ubiquitylation K1171 0.232 _GGK(gl)GLLPVR_

Background Information for IGF1R:


Pubmed-IGF1R »
Uniprot-IGF1R »
Biogrid-IGF1R »
ProteomicsDB-IGF1R »

Tumorportal-IGF1R »
COSMIC-IGF1R »
GenomeRNAi-IGF1R »
Genecards-IGF1R


Protein-protein Interactions for IGF1R
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait INSR Cat. description Hein, Mann, Cell 2015
Category members IP bait LYZL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLAMF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UNC5CL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IGF1R
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19
Category members Tyr_kinase_insulin-like_rcpt IPR016246 0.13
Category members Kinase-like_dom IPR011009 0.03
Category members EGF_rcpt_L IPR000494 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Furin-like_Cys-rich_dom IPR006211 0
Category members Furin_repeat IPR006212 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring IGF1R
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IGF1R
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0030010 establishment of cell polarity Database 0.91
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0032467 positive regulation of cytokinesis Database 0.35
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members GO Category GO:0046328 regulation of JNK cascade Database 0.22
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members Pathway Pathway_450 BIOCARTA_LONGEVITY_PATHWAY 0 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0043559 insulin binding Database 0.04
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0043560 insulin receptor substrate binding Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_212 BIOCARTA_IGF1R_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members GO Category GO:0001965 G-protein alpha-subunit binding Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0005010 insulin-like growth factor-activated receptor activity Database 0
Category members GO Category GO:0005158 insulin receptor binding Database 0
Category members GO Category GO:0005520 insulin-like growth factor binding Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010656 negative regulation of muscle cell apoptotic process Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0030238 male sex determination Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0031017 exocrine pancreas development Database 0
Category members GO Category GO:0031994 insulin-like growth factor I binding Database 0
Category members GO Category GO:0033197 response to vitamin E Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0051054 positive regulation of DNA metabolic process Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060740 prostate gland epithelium morphogenesis Database 0


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