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Query: HNRNPA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HNRNPA1 2 7.536 -1.640 2.570 0.075 -0.732 0.003
HNRNPA1 2 7.536 -1.290 1.410 0.075 -0.732 0.003

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HNRNPA1 Ubiquitylation K350 -0.732 1.588 _SSGPYGGGGQYFAK(gl)PR_
HNRNPA1 Phosphorylation S368 0.872 1.197 _NQGGYGGSSSSSSYGS(ph)GR_
HNRNPA1 Phosphorylation S95 0.849 _EDS(ph)QRPGAHLTVK_
HNRNPA1 Phosphorylation S22 0.705 _LFIGGLS(ph)FETTDESLR_
HNRNPA1 Ubiquitylation K105 0.268 0.130 _EDSQRPGAHLTVK(gl)K_
HNRNPA1 Phosphorylation S6 0.306 0.113 _(ac)S(ph)KSES(ph)PKEPEQLR_
HNRNPA1 Phosphorylation S4 0.422 -0.360 _S(ph)ESPKEPEQLRK_
HNRNPA1 Phosphorylation S337 -0.676 -0.603 _S(ph)SGPYGGGGQYFAK_
HNRNPA1 Phosphorylation S338 -0.603 _S(ph)SGPYGGGGQYFAK_
HNRNPA1 Phosphorylation S2 -0.533 -0.660 _(ac)S(ph)KSES(ph)PKEPEQLR_
HNRNPA1 Ubiquitylation K3 -1.084 -0.893 _(ac)SK(gl)SESPKEPEQLR_
HNRNPA1 Ubiquitylation K8 -0.962 _SESPK(gl)EPEQLR_
HNRNPA1 Ubiquitylation K106 0.268 _EDSQRPGAHLTVKK(gl)_
HNRNPA1 Ubiquitylation K183 1.234 _ALSK(gl)QEMASASSSQR_
HNRNPA1 Phosphorylation S360 0.578 _NQGGYGGS(ph)SSSSSYGSGR_
HNRNPA1 Phosphorylation S361 0.801 _NQGGYGGSS(ph)SSSSYGSGR_

Background Information for HNRNPA1:


Pubmed-HNRNPA1 »
Uniprot-HNRNPA1 »
Biogrid-HNRNPA1 »
ProteomicsDB-HNRNPA1 »

Tumorportal-HNRNPA1 »
COSMIC-HNRNPA1 »
GenomeRNAi-HNRNPA1 »
Genecards-HNRNPA1


Protein-protein Interactions for HNRNPA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait TAF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZWINT Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARP1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MEPCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STRBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUPV3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HNRNPA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members HnRNPA1 IPR021662 0


Protein complexes (CORUM database) featuring HNRNPA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring HNRNPA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0000380 alternative mRNA splicing, via spliceosome Database 0.29
Category members GO Category GO:0051170 nuclear import Database 0.29
Category members GO Category GO:0045111 intermediate filament cytoskeleton Database 0.26
Category members GO Category GO:0006405 RNA export from nucleus Database 0.24
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members Disease phenotype INCLUSION_BODY_MYOPATHY_WITH_EARLY-ONSET_PAGET_DISEASE_WITH_OR_WITHOUT INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT Database 0.11
Category members Disease phenotype Inclusion_body_myopathy_with_Paget_disease_of_bone_and_frontotemporal_dementia Inclusion body myopathy with Paget disease of bone and frontotemporal dementia Database 0.11
Category members GO Category GO:0003727 single-stranded RNA binding Database 0
Category members GO Category GO:0051168 nuclear export Database 0


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