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Query: SQSTM1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SQSTM1 0 -3.532 -0.860 1.770 -2.165 -2.063 -1.741
SQSTM1 0 -3.532 -0.440 0.530 -2.165 -2.063 -1.741

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SQSTM1 Ubiquitylation K13 0.150 0.302 _AYLLGK(gl)EDAAR_
SQSTM1 Phosphorylation S272 0.171 0.044 _LTPVS(ph)PESSSTEEK_
SQSTM1 Phosphorylation S332 -0.007 _IALESEGRPEEQMESDNCS(ph)GGDDDWTHLSSK_
SQSTM1 Ubiquitylation K420 -1.122 -0.061 _LLQTK(gl)NYDIGAALDTIQYSK_
SQSTM1 Phosphorylation T269 -0.681 -0.421 _LT(ph)PVS(ph)PESSSTEEK_
SQSTM1 Ubiquitylation K157 -0.852 -0.677 _CSVCPDYDLCSVCEGK(gl)GLHR_
SQSTM1 Phosphorylation S28 -0.721 _RFSFCCS(ph)PEPEAEAEAAAGPGPCER_
SQSTM1 Ubiquitylation K435 -1.352 -0.780 _NYDIGAALDTIQYSK(gl)HPPPL_
SQSTM1 Ubiquitylation K141 -0.915 _YK(gl)CSVCPDYDLCSVCEGK_

Background Information for SQSTM1:


Pubmed-SQSTM1 »
Uniprot-SQSTM1 »
Biogrid-SQSTM1 »
ProteomicsDB-SQSTM1 »

Tumorportal-SQSTM1 »
COSMIC-SQSTM1 »
GenomeRNAi-SQSTM1 »
Genecards-SQSTM1


Protein-protein Interactions for SQSTM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD44 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF5B Cat. description Hein, Mann, Cell 2015
Category members IP bait MGP Cat. description Hein, Mann, Cell 2015
Category members IP bait PML Cat. description Hein, Mann, Cell 2015
Category members IP bait POC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCI Cat. description Hein, Mann, Cell 2015
Category members IP bait CD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD96 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRHBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KERA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKCZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RETN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCCPDH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SQSTM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBA-like IPR009060 0.17
Category members UBA/transl_elong_EF1B_N_euk IPR015940 0.04
Category members Znf_ZZ IPR000433 0.01
Category members OPR_PB1 IPR000270 0


Protein complexes (CORUM database) featuring SQSTM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2143 MAP2K5-PRKCI-SQSTM1 complex Database 0


Categories featuring SQSTM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0070530 K63-linked polyubiquitin binding Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Disease phenotype PAGET_DISEASE_OF_BONE PAGET DISEASE OF BONE Database 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members GO Category GO:0046578 regulation of Ras protein signal transduction Database 0.03
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_786 REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 0 0
Category members Pathway Pathway_799 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 0 0
Category members Pathway Pathway_803 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL 0 0
Category members Pathway Pathway_806 REACTOME_P75NTR_SIGNALS_VIA_NFKB 0 0
Category members GO Category GO:0000407 pre-autophagosomal structure Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0005776 autophagic vacuole Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0016235 aggresome Database 0
Category members GO Category GO:0016236 macroautophagy Database 0
Category members GO Category GO:0030971 receptor tyrosine kinase binding Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0


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