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Query: PFN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFN1 1 3.703 -0.430 -0.180 0.002 2.497 -0.084 0.348 -0.059

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFN1 Ubiquitylation K126 0.640 0.539 _EGVHGGLINK(gl)K_
PFN1 Ubiquitylation K70 0.186 0.451 _SSFYVNGLTLGGQK(gl)CSVIR_
PFN1 Ubiquitylation K127 0.582 0.353 _EGVHGGLINKK(gl)_
PFN1 Ubiquitylation K54 -0.190 0.319 _TFVNITPAEVGVLVGK(gl)DR_
PFN1 Ubiquitylation K108 0.414 -0.098 _TDK(gl)TLVLLMGK_
PFN1 Ubiquitylation K91 -0.513 -0.205 _TK(gl)STGGAPTFNVTVTK_
PFN1 Ubiquitylation K105 0.309 -0.352 _STGGAPTFNVTVTK(gl)TDK_

Background Information for PFN1:


Pubmed-PFN1 »
Uniprot-PFN1 »
Biogrid-PFN1 »
ProteomicsDB-PFN1 »

Tumorportal-PFN1 »
COSMIC-PFN1 »
GenomeRNAi-PFN1 »
Genecards-PFN1


Protein-protein Interactions for PFN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAST3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015


Protein Domains in PFN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Profilin_chordates IPR005454 0.08
Category members Profilin_eukaryotes/bac IPR005455 0


Protein complexes (CORUM database) featuring PFN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2837 Profilin 1 complex Database 0.21
Category members Corum 3159 RIAM-profilin complex Database 0.17


Categories featuring PFN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_838 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005546 phosphatidylinositol-4,5-bisphosphate binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0070064 proline-rich region binding Database 0.01
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0051054 positive regulation of DNA metabolic process Database 0
Category members GO Category GO:0051496 positive regulation of stress fiber assembly Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0


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