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Query: OPTN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
OPTN 0 0.332

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
OPTN Ubiquitylation K448 -0.263 0.596 _QLQMDEMK(gl)QTIAK_

Background Information for OPTN:


Pubmed-OPTN »
Uniprot-OPTN »
Biogrid-OPTN »
ProteomicsDB-OPTN »

Tumorportal-OPTN »
COSMIC-OPTN »
GenomeRNAi-OPTN »
Genecards-OPTN


Protein-protein Interactions for OPTN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AIMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB3IL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in OPTN
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring OPTN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2241 HD-RAB8A-OPTN complex Database 0.05


Categories featuring OPTN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0043001 Golgi to plasma membrane protein transport Database 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Disease phenotype Amyotrophic_lateral_sclerosis Amyotrophic lateral sclerosis Database 0.21
Category members GO Category GO:0000042 protein targeting to Golgi Database 0.2
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members Disease phenotype GLAUCOMA_PRIMARY_OPEN_ANGLE GLAUCOMA PRIMARY OPEN ANGLE Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0007165 signal transduction Database 0


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