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Query: NLRP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NLRP1 0 -0.868 -0.960 0.730

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NLRP1 Ubiquitylation K297 -1.598 _SQDPLVK(gl)R_

Background Information for NLRP1:


Pubmed-NLRP1 »
Uniprot-NLRP1 »
Biogrid-NLRP1 »
ProteomicsDB-NLRP1 »

Tumorportal-NLRP1 »
COSMIC-NLRP1 »
GenomeRNAi-NLRP1 »
Genecards-NLRP1


Protein-protein Interactions for NLRP1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in NLRP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members DEATH-like_dom IPR011029 1.15
Category members CARD IPR001315 0.55
Category members Leu-rich_rpt IPR001611 0.32
Category members NACHT_NTPase IPR007111 0.23
Category members Leu-rich_rpt_RNase_inh_sub-typ IPR003590 0.06
Category members DAPIN IPR004020 0.05


Protein complexes (CORUM database) featuring NLRP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NLRP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members GO Category GO:0006952 defense response Database 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_1125 PID_ANTHRAX_PATHWAY 0 0.15
Category members GO Category GO:0050718 positive regulation of interleukin-1 beta secretion Database 0.13
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0032495 response to muramyl dipeptide Database 0.06
Category members GO Category GO:0042742 defense response to bacterium Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Disease phenotype Vitiligo-associated_autoimmune_disease Vitiligo-associated autoimmune disease Database 0
Category members GO Category GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process Database 0
Category members GO Category GO:0050727 regulation of inflammatory response Database 0


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