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Query: GNB2L1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNB2L1 1 3.093 1.000 -0.100 0.279 1.704
GNB2L1 1 3.093 1.000 -0.100 -0.278 -0.107 -0.424

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNB2L1 Ubiquitylation K130 0.632 _TIK(gl)LWNTLGVCK_
GNB2L1 Ubiquitylation K38 -0.238 0.350 _DK(gl)TIIMWK_
GNB2L1 Ubiquitylation K271 0.756 -0.007 _IIVDELK(gl)QEVISTSSK_
GNB2L1 Ubiquitylation K175 -0.554 -0.015 _LVK(gl)VWNLANCK_
GNB2L1 Ubiquitylation K185 -0.061 -0.249 _VWNLANCKLK(gl)_
GNB2L1 Ubiquitylation K183 -0.161 -0.282 _VWNLANCK(gl)_
GNB2L1 Ubiquitylation K257 -0.288 _YWLCAATGPSIK(gl)_
GNB2L1 Ubiquitylation K106 -0.290 _RFVGHTK(gl)DVLSVAFSSDNR_

Background Information for GNB2L1:


Pubmed-GNB2L1 »
Uniprot-GNB2L1 »
Biogrid-GNB2L1 »
ProteomicsDB-GNB2L1 »

Tumorportal-GNB2L1 »
COSMIC-GNB2L1 »
GenomeRNAi-GNB2L1 »
Genecards-GNB2L1


Protein-protein Interactions for GNB2L1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGTB Cat. description Hein, Mann, Cell 2015
Category members IP bait LARP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WIPI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNB2L1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12


Protein complexes (CORUM database) featuring GNB2L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1539 G protein complex (GNG2, GNB2L1, RAF1) Database 0.11


Categories featuring GNB2L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0015935 small ribosomal subunit Database 3.99
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0030292 protein tyrosine kinase inhibitor activity Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0043204 perikaryon Database 0.05
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0001891 phagocytic cup Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0008200 ion channel inhibitor activity Database 0
Category members GO Category GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030971 receptor tyrosine kinase binding Database 0
Category members GO Category GO:0032464 positive regulation of protein homooligomerization Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048511 rhythmic process Database 0
Category members GO Category GO:0050765 negative regulation of phagocytosis Database 0
Category members GO Category GO:0051302 regulation of cell division Database 0
Category members GO Category GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0
Category members GO Category GO:0051901 positive regulation of mitochondrial depolarization Database 0
Category members GO Category GO:0061099 negative regulation of protein tyrosine kinase activity Database 0


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