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Query: BAX

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BAX 0 3.185 1.590 -1.170 0.811 0.359

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BAX Ubiquitylation K64 0.708 1.306 _LSECLK(gl)R_
BAX Ubiquitylation K57 -1.174 _MGGEAPELALDPVPQDASTK(gl)K_
BAX Ubiquitylation K58 -1.718 -1.174 _MGGEAPELALDPVPQDASTKK(gl)_

Background Information for BAX:


Pubmed-BAX »
Uniprot-BAX »
Biogrid-BAX »
ProteomicsDB-BAX »

Tumorportal-BAX »
COSMIC-BAX »
GenomeRNAi-BAX »
Genecards-BAX


Protein-protein Interactions for BAX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAX Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL2L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BAX
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Blc2_fam IPR026298 0.14
Category members Bcl2-like IPR002475 0.05


Protein complexes (CORUM database) featuring BAX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BAX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0051881 regulation of mitochondrial membrane potential Database 1.57
Category members GO Category GO:0046930 pore complex Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0010248 establishment or maintenance of transmembrane electrochemical gradient Database 0.63
Category members GO Category GO:0048597 post-embryonic camera-type eye morphogenesis Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_754 SA_PROGRAMMED_CELL_DEATH 0 0.61
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members GO Category GO:0033599 regulation of mammary gland epithelial cell proliferation Database 0.34
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0002262 myeloid cell homeostasis Database 0.3
Category members GO Category GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration Database 0.3
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0008053 mitochondrial fusion Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0002352 B cell negative selection Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0001783 B cell apoptotic process Database 0.23
Category members GO Category GO:0033137 negative regulation of peptidyl-serine phosphorylation Database 0.21
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members GO Category GO:0006808 regulation of nitrogen utilization Database 0.17
Category members GO Category GO:0048087 positive regulation of developmental pigmentation Database 0.17
Category members GO Category GO:0070242 thymocyte apoptotic process Database 0.13
Category members GO Category GO:0043496 regulation of protein homodimerization activity Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0060058 positive regulation of apoptotic process involved in mammary gland involution Database 0.08
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0046666 retinal cell programmed cell death Database 0.08
Category members GO Category GO:0043497 regulation of protein heterodimerization activity Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0048872 homeostasis of number of cells Database 0.05
Category members GO Category GO:0009651 response to salt stress Database 0.04
Category members GO Category GO:0048515 spermatid differentiation Database 0.04
Category members GO Category GO:0060011 Sertoli cell proliferation Database 0.04
Category members GO Category GO:0048873 homeostasis of number of cells within a tissue Database 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0001782 B cell homeostasis Database 0.02
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_883 KEGG_PRION_DISEASES 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members GO Category GO:0001101 response to acid Database 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001776 leukocyte homeostasis Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001974 blood vessel remodeling Database 0
Category members GO Category GO:0002358 B cell homeostatic proliferation Database 0
Category members GO Category GO:0002904 positive regulation of B cell apoptotic process Database 0
Category members GO Category GO:0006687 glycosphingolipid metabolic process Database 0
Category members GO Category GO:0006927 transformed cell apoptotic process Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007548 sex differentiation Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Database 0
Category members GO Category GO:0009566 fertilization Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010524 positive regulation of calcium ion transport into cytosol Database 0
Category members GO Category GO:0015267 channel activity Database 0
Category members GO Category GO:0021854 hypothalamus development Database 0
Category members GO Category GO:0030264 nuclear fragmentation involved in apoptotic nuclear change Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0032461 positive regulation of protein oligomerization Database 0
Category members GO Category GO:0035108 limb morphogenesis Database 0
Category members GO Category GO:0035234 germ cell programmed cell death Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043523 regulation of neuron apoptotic process Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0043653 mitochondrial fragmentation involved in apoptotic process Database 0
Category members GO Category GO:0045136 development of secondary sexual characteristics Database 0
Category members GO Category GO:0048147 negative regulation of fibroblast proliferation Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0051281 positive regulation of release of sequestered calcium ion into cytosol Database 0
Category members GO Category GO:0051434 BH3 domain binding Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0
Category members GO Category GO:0060068 vagina development Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0


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