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Query: TSC2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TSC2 1 2.350 0.810 -0.710
TSC2 1 2.350 0.810 -0.710 -0.715

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TSC2 Ubiquitylation K634 1.610 _LGLPNK(gl)DGVVR_
TSC2 Phosphorylation S1362 0.859 _S(ph)QSGTLDGESAAWSASGEDSR_
TSC2 Phosphorylation S1364 0.522 0.550 _SQS(ph)GTLDGESAAWSASGEDSR_
TSC2 Phosphorylation S1396 0.498 _S(ph)PSGLRPR_
TSC2 Phosphorylation S1355 0.174 0.351 _ADVGRLS(ph)PEVK_
TSC2 Ubiquitylation K69 0.051 _MIGQICEVAK(gl)TK_
TSC2 Phosphorylation S1332 -0.063 _SSSS(ph)PELQTLQDILGDPGDK_
TSC2 Ubiquitylation K71 -0.157 _MIGQICEVAKTK(gl)_
TSC2 Ubiquitylation K258 -0.278 _ELCEPCWK(gl)LMR_
TSC2 Phosphorylation S950 -0.152 -0.529 _STS(ph)LNERPK_
TSC2 Phosphorylation S1248 -0.604 _SNTDSAVVMEEGS(ph)PGEVPVLVEPPGLEDVEAALGMDRR_
TSC2 Phosphorylation S1064 -0.927 _SLLGLDSGELQSGPESSSS(ph)PGVHVR_
TSC2 Ubiquitylation K14 -1.297 _DSGLKEK(gl)FK_
TSC2 Ubiquitylation K3 -1.397 _(ac)AK(gl)PTSKDSGLK_
TSC2 Phosphorylation S1329 -0.120 _S(ph)SSSPELQTLQDILGDPGDK_
TSC2 Phosphorylation S1331 -0.262 _SSS(ph)SPELQTLQDILGDPGDKADVGR_
TSC2 Phosphorylation T1366 0.137 _SQSGT(ph)LDGESAAWSASGEDSR_
TSC2 Phosphorylation S1743 0.596 _RLISS(ph)VEDFTEFV_

Background Information for TSC2:


Pubmed-TSC2 »
Uniprot-TSC2 »
Biogrid-TSC2 »
ProteomicsDB-TSC2 »

Tumorportal-TSC2 »
COSMIC-TSC2 »
GenomeRNAi-TSC2 »
Genecards-TSC2


Protein-protein Interactions for TSC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TBC1D7 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf128 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COL20A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKCSH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TSC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Rap_GAP_dom IPR000331 0.02


Protein complexes (CORUM database) featuring TSC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 75 TSC1-TSC2 complex Database 0.13


Categories featuring TSC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_708 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members Pathway Pathway_991 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008104 protein localization Database 0.5
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0032007 negative regulation of TOR signaling Database 0.33
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0045792 negative regulation of cell size Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_945 BIOCARTA_VDR_PATHWAY 0 0.22
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members Disease phenotype LYMPHANGIOLEIOMYOMATOSIS LYMPHANGIOLEIOMYOMATOSIS Database 0.13
Category members Disease phenotype Tuberous_sclerosis Tuberous sclerosis Database 0.13
Category members GO Category GO:0033596 TSC1-TSC2 complex Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0045184 establishment of protein localization Database 0.1
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_1150 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 0 0.04
Category members GO Category GO:0046626 regulation of insulin receptor signaling pathway Database 0.04
Category members Pathway Pathway_1258 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 0 0.04
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members Disease phenotype Autosomal_dominant_polycystic_kidney_disease_type_1_with_tuberous_sclerosis Autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis Database 0.04
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0006953 acute-phase response Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0030030 cell projection organization Database 0
Category members GO Category GO:0030100 regulation of endocytosis Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0050918 positive chemotaxis Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0


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