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Query: KRAS

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KRAS 1 5.499 -0.510 0.620 0.246 -0.346
KRAS 1 5.499 -0.510 0.620 1.031 0.887

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KRAS Ubiquitylation K128 1.528 1.433 _TVDTK(gl)QAHELAK_
KRAS Ubiquitylation K235 0.591 0.087 _TVDTK(gl)QAQDLAR_
KRAS Ubiquitylation K254 -0.450 -0.156 _SYGIPFIETSAK(gl)TR_

Background Information for KRAS:


Pubmed-KRAS »
Uniprot-KRAS »
Biogrid-KRAS »
ProteomicsDB-KRAS »

Tumorportal-KRAS »
COSMIC-KRAS »
GenomeRNAi-KRAS »
Genecards-KRAS


Protein-protein Interactions for KRAS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait EEA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FRAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KRAS Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZMYND8 Cat. description Hein, Mann, Cell 2015
Category members IP bait BRAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KRAS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32


Protein complexes (CORUM database) featuring KRAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5922 RAF1-RAS complex, EGF induced Database 0.13


Categories featuring KRAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051146 striated muscle cell differentiation Database 1.01
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_583 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 0 0.68
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_688 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 0 0.47
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_1004 REACTOME_ARMS_MEDIATED_ACTIVATION 0 0.4
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Disease phenotype RAS-associated_autoimmune_lymphoproliferative_disease RAS-associated autoimmune lymphoproliferative disease Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0035022 positive regulation of Rac protein signal transduction Database 0.26
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0032228 regulation of synaptic transmission, GABAergic Database 0.19
Category members Disease phenotype NOONAN_SYNDROME NOONAN SYNDROME Database 0.19
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Disease phenotype Hereditary_nonpolyposis_colon_cancer Hereditary nonpolyposis colon cancer Database 0.14
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members Pathway Pathway_685 PID_RAS_PATHWAY 0 0.14
Category members Pathway Pathway_694 REACTOME_SIGNALLING_TO_ERKS 0 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Disease phenotype PILOCYTIC_ASTROCYTOMA_SOMATIC PILOCYTIC ASTROCYTOMA SOMATIC Database 0.09
Category members Disease phenotype Juvenile_myelomonocytic_leukemia Juvenile myelomonocytic leukemia Database 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0030275 LRR domain binding Database 0.08
Category members Disease phenotype Familial_pancreatic_carcinoma Familial pancreatic carcinoma Database 0.06
Category members Disease phenotype CARDIOFACIOCUTANEOUS_SYNDROME CARDIOFACIOCUTANEOUS SYNDROME Database 0.06
Category members Disease phenotype cardiofaciocutaneous_syndrome_(CFC_syndrome) cardiofaciocutaneous syndrome (CFC syndrome) Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Pathway Pathway_1003 PID_TCR_RAS_PATHWAY 0 0.05
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_1115 REACTOME_SOS_MEDIATED_SIGNALLING 0 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_1118 REACTOME_RAF_MAP_KINASE_CASCADE 0 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_1002 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 0 0
Category members Pathway Pathway_1006 PID_MAPK_TRK_PATHWAY 0 0
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1066 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 0 0
Category members Pathway Pathway_1070 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 0 0
Category members Pathway Pathway_1073 KEGG_DORSO_VENTRAL_AXIS_FORMATION 0 0
Category members Pathway Pathway_1088 REACTOME_SHC_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1091 REACTOME_FRS2_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1108 REACTOME_SHC_RELATED_EVENTS 0 0
Category members Pathway Pathway_1111 REACTOME_SHC_MEDIATED_SIGNALLING 0 0
Category members Pathway Pathway_1112 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 0 0
Category members Pathway Pathway_1114 REACTOME_SIGNALLING_TO_RAS 0 0
Category members Pathway Pathway_1117 REACTOME_P38MAPK_EVENTS 0 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_512 REACTOME_IL_2_SIGNALING 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_586 REACTOME_TIE2_SIGNALING 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members Disease phenotype Gastric_cancer Gastric cancer Database 0
Category members Disease phenotype LEUKEMIA_ACUTE_MYELOID LEUKEMIA ACUTE MYELOID Database 0
Category members Disease phenotype Linear_nevus_sebaceus_syndrome Linear nevus sebaceus syndrome Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0019002 GMP binding Database 0
Category members GO Category GO:0035176 social behavior Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0048169 regulation of long-term neuronal synaptic plasticity Database 0
Category members GO Category GO:0051000 positive regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051385 response to mineralocorticoid Database 0


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