bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: NEDD4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEDD4 0 1.048 -1.320 1.730

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEDD4 Ubiquitylation K882 -0.919 0.114 _GK(gl)TSLDTSNDLGPLPPGWEER_
NEDD4 Phosphorylation Y751 -0.924 _RGSLQAY(ph)TFEEQPTLPVLLPTSSGLPPGWEEK_
NEDD4 Ubiquitylation K874 0.127 _LK(gl)IPAHLR_

Background Information for NEDD4:


Pubmed-NEDD4 »
Uniprot-NEDD4 »
Biogrid-NEDD4 »
ProteomicsDB-NEDD4 »

Tumorportal-NEDD4 »
COSMIC-NEDD4 »
GenomeRNAi-NEDD4 »
Genecards-NEDD4


Protein-protein Interactions for NEDD4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARRDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C12orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM70A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILDR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0247 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OCLN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRRG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMURF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM171 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM51 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEDD4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members HECT IPR000569 0.04
Category members C2_dom IPR000008 0


Protein complexes (CORUM database) featuring NEDD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NEDD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0003197 endocardial cushion development Database 0.31
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Database 0.09
Category members GO Category GO:0050816 phosphothreonine binding Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0042921 glucocorticoid receptor signaling pathway Database 0.04
Category members GO Category GO:0010766 negative regulation of sodium ion transport Database 0.04
Category members GO Category GO:0016327 apicolateral plasma membrane Database 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0031623 receptor internalization Database 0.02
Category members GO Category GO:0006622 protein targeting to lysosome Database 0.02
Category members GO Category GO:0034765 regulation of ion transmembrane transport Database 0.02
Category members GO Category GO:0070064 proline-rich region binding Database 0.01
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members GO Category GO:0002250 adaptive immune response Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0007041 lysosomal transport Database 0
Category members GO Category GO:0007528 neuromuscular junction development Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0019871 sodium channel inhibitor activity Database 0
Category members GO Category GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0031698 beta-2 adrenergic receptor binding Database 0
Category members GO Category GO:0032801 receptor catabolic process Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0048514 blood vessel morphogenesis Database 0
Category members GO Category GO:0048814 regulation of dendrite morphogenesis Database 0
Category members GO Category GO:0050807 regulation of synapse organization Database 0
Category members GO Category GO:0050815 phosphoserine binding Database 0
Category members GO Category GO:0050847 progesterone receptor signaling pathway Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0070063 RNA polymerase binding Database 0
Category members GO Category GO:0070534 protein K63-linked ubiquitination Database 0


.

© Copyright Svejstrup Laboratory 2015