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Query: WWOX

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WWOX 1 -1.751 2.850 -1.200

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WWOX Ubiquitylation K100 -1.048 -0.703 _LAFTVDDNPTK(gl)PTTR_

Background Information for WWOX:


Pubmed-WWOX »
Uniprot-WWOX »
Biogrid-WWOX »
ProteomicsDB-WWOX »

Tumorportal-WWOX »
COSMIC-WWOX »
GenomeRNAi-WWOX »
Genecards-WWOX


Protein-protein Interactions for WWOX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GORASP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM171 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWOX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WWOX
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members DH_sc/Rdtase_SDR IPR002198 0
Category members Glc/ribitol_DH IPR002347 0
Category members PKS_KR IPR013968 0


Protein complexes (CORUM database) featuring WWOX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring WWOX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0005902 microvillus Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Disease phenotype ESOPHAGEAL_CANCER ESOPHAGEAL CANCER Database 0.05
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members Disease phenotype 46XY_partial_gonadal_dysgenesis 46XY partial gonadal dysgenesis Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0008202 steroid metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048705 skeletal system morphogenesis Database 0
Category members GO Category GO:0050662 coenzyme binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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