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Query: RPA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RPA1 6 17.561 0.500 0.350 3.133 3.046 0.303 1.770 2.112

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RPA1 Ubiquitylation K163 2.827 4.085 _AYGASK(gl)TFGK_
RPA1 Ubiquitylation K331 3.112 4.066 _SYEDATK(gl)ITVR_
RPA1 Ubiquitylation K167 3.009 3.243 _TFGK(gl)AAGPSLSHTSGGTQSK_
RPA1 Ubiquitylation K489 0.465 2.335 _K(gl)VIDQQNGLYR_
RPA1 Ubiquitylation K183 0.925 _AAGPSLSHTSGGTQSK(gl)VVPIASLTPYQSK_
RPA1 Ubiquitylation K263 -1.803 _GTLK(gl)IANK_
RPA1 Ubiquitylation K267 2.751 _IANK(gl)QFTAVK_
RPA1 Ubiquitylation K410 2.458 _SLSVLSSSTIIANPDIPEAYK(gl)LR_
RPA1 Ubiquitylation K588 -0.055 _IK(gl)ATVMDVKPVDYR_
RPA1 Ubiquitylation K595 1.201 _ATVMDVK(gl)PVDYR_

Background Information for RPA1:


Pubmed-RPA1 »
Uniprot-RPA1 »
Biogrid-RPA1 »
ProteomicsDB-RPA1 »

Tumorportal-RPA1 »
COSMIC-RPA1 »
GenomeRNAi-RPA1 »
Genecards-RPA1


Protein-protein Interactions for RPA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RPA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait MACROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPAIN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RPA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members NA-bd_OB_tRNA IPR004365 0.35


Protein complexes (CORUM database) featuring RPA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5231 53BP1-containing complex Database 1.75
Category members Corum 5229 RPA complex Database 0.89
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 2222 BLM complex II Database 0.3
Category members Corum 2738 BLM complex II Database 0.3
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 997 KIN17-PCNA-RPA70 complex Database 0.14
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0


Categories featuring RPA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0006261 DNA-dependent DNA replication Database 0.48
Category members GO Category GO:0001673 male germ cell nucleus Database 0.44
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members GO Category GO:0005662 DNA replication factor A complex Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0000730 DNA recombinase assembly Database 0.31
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0006297 nucleotide-excision repair, DNA gap filling Database 0.25
Category members Pathway Pathway_340 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND 0 0.24
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members Pathway Pathway_333 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER 0 0.08
Category members GO Category GO:0048873 homeostasis of number of cells within a tissue Database 0.04
Category members GO Category GO:0007126 meiosis Database 0.01
Category members GO Category GO:0000800 lateral element Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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