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Query: BRAF

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BRAF 0 1.202

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BRAF Phosphorylation S447 0.579 0.623 _RDSS(ph)DDWEIPDGQITVGQR_
BRAF Phosphorylation S446 0.246 0.349 _RDS(ph)SDDWEIPDGQITVGQR_
BRAF Phosphorylation S729 0.208 0.219 _SAS(ph)EPSLNR_
BRAF Phosphorylation S365 -0.286 0.012 _SSS(ph)APNVHINTIEPVNIDDLIR_
BRAF Phosphorylation S363 -0.023 -0.241 _S(ph)SSAPNVHINTIEPVNIDDLIR_
BRAF Phosphorylation S399 -0.890 -0.527 _GDGGSTTGLS(ph)ATPPASLPGSLTNVK_
BRAF Phosphorylation S151 -0.685 -0.629 _SNPKS(ph)PQKPIVR_
BRAF Phosphorylation T401 -0.525 _GDGGSTTGLSAT(ph)PPASLPGSLTNVK_

Background Information for BRAF:


Pubmed-BRAF »
Uniprot-BRAF »
Biogrid-BRAF »
ProteomicsDB-BRAF »

Tumorportal-BRAF »
COSMIC-BRAF »
GenomeRNAi-BRAF »
Genecards-BRAF


Protein-protein Interactions for BRAF
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAP2K1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS4B Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAZ Cat. description Hein, Mann, Cell 2015
Category members IP bait BRAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FKBPL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BRAF
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Raf-like_ras-bd IPR003116 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring BRAF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5919 BRAF-RAF1-14-3-3 complex Database 1.97
Category members Corum 5877 MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex Database 0.31
Category members Corum 5923 RAF1-BRAF complex, RAS stimulated Database 0.09
Category members Corum 5872 BRAF-MAP2K1-MAP2K2-YWHAE complex Database 0.06
Category members Corum 5921 KSR1-BRAF-MEK complex Database 0
Category members Corum 5925 BRAF-CNK1 complex, not RAS stimulated Database 0


Categories featuring BRAF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_688 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 0 0.47
Category members Pathway Pathway_1004 REACTOME_ARMS_MEDIATED_ACTIVATION 0 0.4
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Disease phenotype COLORECTAL_CANCER COLORECTAL CANCER Database 0.29
Category members Disease phenotype LEOPARD_SYNDROME LEOPARD SYNDROME Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Disease phenotype NOONAN_SYNDROME NOONAN SYNDROME Database 0.19
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_694 REACTOME_SIGNALLING_TO_ERKS 0 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_733 ST_G_ALPHA_S_PATHWAY 0 0.13
Category members Disease phenotype LUNG_CANCER LUNG CANCER Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Disease phenotype PILOCYTIC_ASTROCYTOMA_SOMATIC PILOCYTIC ASTROCYTOMA SOMATIC Database 0.09
Category members Disease phenotype Craniopharyngioma Craniopharyngioma Database 0.09
Category members Pathway Pathway_810 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 0 0.09
Category members GO Category GO:0004709 MAP kinase kinase kinase activity Database 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_1005 ST_ERK1_ERK2_MAPK_PATHWAY 0 0.06
Category members Disease phenotype CARDIOFACIOCUTANEOUS_SYNDROME CARDIOFACIOCUTANEOUS SYNDROME Database 0.06
Category members Disease phenotype cardiofaciocutaneous_syndrome_(CFC_syndrome) cardiofaciocutaneous syndrome (CFC syndrome) Database 0.06
Category members Pathway Pathway_1003 PID_TCR_RAS_PATHWAY 0 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1002 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 0 0
Category members Pathway Pathway_1006 PID_MAPK_TRK_PATHWAY 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_224 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_238 REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_935 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0005057 receptor signaling protein activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031434 mitogen-activated protein kinase kinase binding Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0070849 response to epidermal growth factor Database 0
Category members GO Category GO:0071277 cellular response to calcium ion Database 0
Category members Human mutations pubmedid:22842228 Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. (Krauthammer et al, Nat. Genet. 2012 Research article 0


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