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bioLOGIC Data

Query: CAB39

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
CAB39	0	1.662	-0.920	0.670

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
CAB39	Ubiquitylation	K20	0.992		_NLK(gl)ESMAVLEK_

Background Information for CAB39:

Pubmed-CAB39 »

Uniprot-CAB39 »

Biogrid-CAB39 »

ProteomicsDB-CAB39 »

Tumorportal-CAB39 »

COSMIC-CAB39 »

GenomeRNAi-CAB39 »

Genecards-CAB39

Protein-protein Interactions for CAB39

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait AHCYL2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait C5orf24	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CAB39L	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CYP1A1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait FGB	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait GTF2E2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PIP4K2A	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait STK11	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait STK25	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait STRADB	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in CAB39

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	ARM-type_fold	IPR016024	9.26
Category members	Mo25	IPR013878	0

Protein complexes (CORUM database) featuring CAB39

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	6053	LKB1-STRAD-MO25 complex	Database	0

Categories featuring CAB39

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005829	cytosol	Database	INF
Category members	GO Category	GO:0005488	binding	Database	9.32
Category members	GO Category	GO:0043234	protein complex	Database	2.73
Category members	GO Category	GO:0004674	protein serine/threonine kinase activity	Database	0.66
Category members	Pathway	Pathway_1142	PID_LKB1_PATHWAY	0	0.6
Category members	GO Category	GO:0019900	kinase binding	Database	0.45
Category members	GO Category	GO:0008286	insulin receptor signaling pathway	Database	0.2
Category members	Pathway	Pathway_1149	REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1	0	0.19
Category members	GO Category	GO:0045860	positive regulation of protein kinase activity	Database	0.06
Category members	Pathway	Pathway_1150	REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK	0	0.04
Category members	Pathway	Pathway_153	REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE	0	0
Category members	Pathway	Pathway_190	REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	0	0
Category members	Pathway	Pathway_302	REACTOME_PKB_MEDIATED_EVENTS	0	0
Category members	Pathway	Pathway_303	REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	0	0
Category members	Pathway	Pathway_304	REACTOME_PI3K_CASCADE	0	0
Category members	Pathway	Pathway_554	KEGG_MTOR_SIGNALING_PATHWAY	0	0
Category members	GO Category	GO:0007050	cell cycle arrest	Database	0
Category members	GO Category	GO:0030295	protein kinase activator activity	Database	0
Category members	GO Category	GO:0032147	activation of protein kinase activity	Database	0
Category members	GO Category	GO:0051291	protein heterooligomerization	Database	0