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Query: EIF4B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF4B 0 -0.215 -0.020 0.470 -0.169 -0.233 -0.211 -0.927 -0.212

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF4B Phosphorylation S283 0.453 0.543 _AFGS(ph)GYR_
EIF4B Phosphorylation S207 -0.235 0.162 _ARPATDS(ph)FDDYPPR_
EIF4B Phosphorylation S464 -0.446 0.097 _EEDCHS(ph)PTSKPPKPDQPLK_
EIF4B Phosphorylation S93 -0.425 -0.444 _S(ph)PPYTAFLGNLPYDVTEESIKEFFR_
EIF4B Ubiquitylation K365 0.071 _AASIFGGAK(gl)PVDTAAR_

Background Information for EIF4B:


Pubmed-EIF4B »
Uniprot-EIF4B »
Biogrid-EIF4B »
ProteomicsDB-EIF4B »

Tumorportal-EIF4B »
COSMIC-EIF4B »
GenomeRNAi-EIF4B »
Genecards-EIF4B


Protein-protein Interactions for EIF4B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC25B Cat. description Hein, Mann, Cell 2015
Category members IP bait CREBBP Cat. description Hein, Mann, Cell 2015
Category members IP bait ERCC6L Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA10 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTEN Cat. description Hein, Mann, Cell 2015
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait TTLL12 Cat. description Hein, Mann, Cell 2015
Category members IP bait WIZ Cat. description Hein, Mann, Cell 2015


Protein Domains in EIF4B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34


Protein complexes (CORUM database) featuring EIF4B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF4B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0016281 eukaryotic translation initiation factor 4F complex Database 0.08
Category members GO Category GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening Database 0.06
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_839 REACTOME_MTORC1_MEDIATED_SIGNALLING 0 0
Category members Pathway Pathway_841 REACTOME_DEADENYLATION_OF_MRNA 0 0


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