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Query: MLST8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MLST8 0 0.087 -0.170 0.220

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MLST8 Ubiquitylation K245 -0.114 0.462 _FSPDSTLLATCSADQTCK(gl)IWR_
MLST8 Phosphorylation T3 -0.481 _(ac)MNT(ph)SPGTVGSDPVILATAGYDHTVR_

Background Information for MLST8:


Pubmed-MLST8 »
Uniprot-MLST8 »
Biogrid-MLST8 »
ProteomicsDB-MLST8 »

Tumorportal-MLST8 »
COSMIC-MLST8 »
GenomeRNAi-MLST8 »
Genecards-MLST8


Protein-protein Interactions for MLST8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLMP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLST8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC30A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MLST8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12


Protein complexes (CORUM database) featuring MLST8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3979 mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR, SIN1) Database 0.04
Category members Corum 1893 mTOR-RICTOR complex Database 0
Category members Corum 1897 RAPTOR-mTOR complex Database 0
Category members Corum 2969 mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR) Database 0
Category members Corum 2970 mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR) Database 0
Category members Corum 2990 mTOR-signaling complex (FRAP1/mTOR, GBL, RAPTOR) Database 0
Category members Corum 3980 mTOR-RAPTOR complex Database 0


Categories featuring MLST8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_708 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0030838 positive regulation of actin filament polymerization Database 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_622 REACTOME_CD28_CO_STIMULATION 0 0.13
Category members GO Category GO:0032314 regulation of Rac GTPase activity Database 0.11
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_551 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_839 REACTOME_MTORC1_MEDIATED_SIGNALLING 0 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0032008 positive regulation of TOR signaling Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0


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