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Query: STK11

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STK11 0 1.504

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STK11 Phosphorylation T32 1.256 0.248 _IDS(ph)TEVIYQPR_
STK11 Phosphorylation S31 0.437 0.073 _IDS(ph)TEVIYQPR_

Background Information for STK11:


Pubmed-STK11 »
Uniprot-STK11 »
Biogrid-STK11 »
ProteomicsDB-STK11 »

Tumorportal-STK11 »
COSMIC-STK11 »
GenomeRNAi-STK11 »
Genecards-STK11


Protein-protein Interactions for STK11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C5orf24 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAB39L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STRADB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STK11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring STK11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 6053 LKB1-STRAD-MO25 complex Database 0


Categories featuring STK11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0030010 establishment of cell polarity Database 0.91
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0051896 regulation of protein kinase B signaling Database 0.62
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0033762 response to glucagon Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0001944 vasculature development Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1149 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 0 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0045059 positive thymic T cell selection Database 0.11
Category members GO Category GO:0030111 regulation of Wnt signaling pathway Database 0.08
Category members GO Category GO:0030275 LRR domain binding Database 0.08
Category members GO Category GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway Database 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1150 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 0 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_153 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Disease phenotype TESTICULAR_GERM_CELL_TUMOR TESTICULAR GERM CELL TUMOR Database 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0001558 regulation of cell growth Database 0
Category members GO Category GO:0001894 tissue homeostasis Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007286 spermatid development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030295 protein kinase activator activity Database 0
Category members GO Category GO:0032147 activation of protein kinase activity Database 0
Category members GO Category GO:0033993 response to lipid Database 0
Category members GO Category GO:0042304 regulation of fatty acid biosynthetic process Database 0
Category members GO Category GO:0043276 anoikis Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0045722 positive regulation of gluconeogenesis Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050772 positive regulation of axonogenesis Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051645 Golgi localization Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development Database 0


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