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Query: TSC1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TSC1 0 0.491 1.100 -0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TSC1 Phosphorylation S505 0.141 0.350 _GGFDS(ph)PFYR_

Background Information for TSC1:


Pubmed-TSC1 »
Uniprot-TSC1 »
Biogrid-TSC1 »
ProteomicsDB-TSC1 »

Tumorportal-TSC1 »
COSMIC-TSC1 »
GenomeRNAi-TSC1 »
Genecards-TSC1


Protein-protein Interactions for TSC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TBC1D7 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKTIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TSC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26


Protein complexes (CORUM database) featuring TSC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 75 TSC1-TSC2 complex Database 0.13


Categories featuring TSC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0032007 negative regulation of TOR signaling Database 0.33
Category members GO Category GO:0045792 negative regulation of cell size Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0042552 myelination Database 0.16
Category members Disease phenotype LYMPHANGIOLEIOMYOMATOSIS LYMPHANGIOLEIOMYOMATOSIS Database 0.13
Category members Disease phenotype Tuberous_sclerosis Tuberous sclerosis Database 0.13
Category members GO Category GO:0033596 TSC1-TSC2 complex Database 0.13
Category members GO Category GO:0006813 potassium ion transport Database 0.11
Category members GO Category GO:0001952 regulation of cell-matrix adhesion Database 0.11
Category members GO Category GO:0050808 synapse organization Database 0.08
Category members GO Category GO:0005884 actin filament Database 0.08
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members Pathway Pathway_1150 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 0 0.04
Category members Pathway Pathway_1258 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 0 0.04
Category members GO Category GO:0045859 regulation of protein kinase activity Database 0.01
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0006407 rRNA export from nucleus Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0030030 cell projection organization Database 0
Category members GO Category GO:0030695 GTPase regulator activity Database 0
Category members GO Category GO:0032794 GTPase activating protein binding Database 0
Category members GO Category GO:0032862 activation of Rho GTPase activity Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0043666 regulation of phosphoprotein phosphatase activity Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051492 regulation of stress fiber assembly Database 0
Category members GO Category GO:0051893 regulation of focal adhesion assembly Database 0
Category members GO Category GO:0051894 positive regulation of focal adhesion assembly Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0


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