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Query: PRKAA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKAA2 0 -0.556 -0.030 -0.350

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKAA2 Ubiquitylation K271 -0.536 _ATIK(gl)DIR_
PRKAA2 Phosphorylation S377 -0.020 _MPPLIADS(ph)PK_

Background Information for PRKAA2:


Pubmed-PRKAA2 »
Uniprot-PRKAA2 »
Biogrid-PRKAA2 »
ProteomicsDB-PRKAA2 »

Tumorportal-PRKAA2 »
COSMIC-PRKAA2 »
GenomeRNAi-PRKAA2 »
Genecards-PRKAA2


Protein-protein Interactions for PRKAA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NIPSNAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTNNA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCLRE1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STIM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKAA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members KA1/Ssp2_C IPR028375 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKAA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRKAA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0032007 negative regulation of TOR signaling Database 0.33
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1149 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 0 0.19
Category members GO Category GO:0004679 AMP-activated protein kinase activity Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0055089 fatty acid homeostasis Database 0.14
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0008610 lipid biosynthetic process Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1150 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 0 0.04
Category members Pathway Pathway_1258 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 0 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_153 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE 0 0
Category members Pathway Pathway_155 BIOCARTA_LEPTIN_PATHWAY 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_526 KEGG_REGULATION_OF_AUTOPHAGY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006633 fatty acid biosynthetic process Database 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0006853 carnitine shuttle Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010508 positive regulation of autophagy Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031669 cellular response to nutrient levels Database 0
Category members GO Category GO:0035174 histone serine kinase activity Database 0
Category members GO Category GO:0035404 histone-serine phosphorylation Database 0
Category members GO Category GO:0042149 cellular response to glucose starvation Database 0
Category members GO Category GO:0042304 regulation of fatty acid biosynthetic process Database 0
Category members GO Category GO:0042752 regulation of circadian rhythm Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0045821 positive regulation of glycolysis Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Database 0
Category members GO Category GO:0048511 rhythmic process Database 0
Category members GO Category GO:0050405 [acetyl-CoA carboxylase] kinase activity Database 0


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