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Query: RPTOR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RPTOR 0 2.349 0.520 -1.030 0.623 0.466

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RPTOR Phosphorylation S722 0.393 1.196 _SVSS(ph)YGNIR_
RPTOR Phosphorylation S863 -0.208 -0.001 _VLDTSSLTQS(ph)APAS(ph)PTNK_
RPTOR Phosphorylation S877 -0.114 -0.074 _GVHIHQAGGS(ph)PPASSTSSSSLTNDVAK_
RPTOR Phosphorylation T865 -0.317 _VLDTSSLTQS(ph)APASPT(ph)NK_
RPTOR Ubiquitylation K1008 -0.329 _QAQQVIQK(gl)GITR_
RPTOR Phosphorylation S859 -0.462 -0.346 _VLDTSSLTQS(ph)APASPT(ph)NK_
RPTOR Phosphorylation T857 -0.348 _VLDTSSLT(ph)QSAPAS(ph)PTNK_

Background Information for RPTOR:


Pubmed-RPTOR »
Uniprot-RPTOR »
Biogrid-RPTOR »
ProteomicsDB-RPTOR »

Tumorportal-RPTOR »
COSMIC-RPTOR »
GenomeRNAi-RPTOR »
Genecards-RPTOR


Protein-protein Interactions for RPTOR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait BRAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CXorf48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTU Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IQCF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NTRK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMEL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRAGA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNDC15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RPTOR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members HEAT IPR000357 3.83
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring RPTOR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1897 RAPTOR-mTOR complex Database 0
Category members Corum 2970 mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR) Database 0
Category members Corum 2990 mTOR-signaling complex (FRAP1/mTOR, GBL, RAPTOR) Database 0
Category members Corum 3980 mTOR-RAPTOR complex Database 0


Categories featuring RPTOR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_1149 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 0 0.19
Category members GO Category GO:0008361 regulation of cell size Database 0.06
Category members Pathway Pathway_1150 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 0 0.04
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_839 REACTOME_MTORC1_MEDIATED_SIGNALLING 0 0
Category members GO Category GO:0001030 RNA polymerase III type 1 promoter DNA binding Database 0
Category members GO Category GO:0001031 RNA polymerase III type 2 promoter DNA binding Database 0
Category members GO Category GO:0001032 RNA polymerase III type 3 promoter DNA binding Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0031669 cellular response to nutrient levels Database 0
Category members GO Category GO:0031929 TOR signaling Database 0
Category members GO Category GO:0031931 TORC1 complex Database 0
Category members GO Category GO:0032008 positive regulation of TOR signaling Database 0
Category members GO Category GO:0042325 regulation of phosphorylation Database 0
Category members GO Category GO:0045945 positive regulation of transcription from RNA polymerase III promoter Database 0
Category members GO Category GO:0071230 cellular response to amino acid stimulus Database 0


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