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Query: EIF2S3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2S3 1 2.867 0.380 0.280 0.168
EIF2S3 1 2.867 0.380 0.280 0.842 -0.253 0.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2S3 Ubiquitylation K125 -0.886 1.674 _GNFK(gl)LVR_
EIF2S3 Ubiquitylation K421 0.258 1.210 _VSAVK(gl)ADLGK_
EIF2S3 Ubiquitylation K440 0.386 1.041 _IVLTNPVCTEVGEK(gl)IALSR_
EIF2S3 Ubiquitylation K87 -0.553 1.040 _LGYANAK(gl)IYK_
EIF2S3 Ubiquitylation K196 -0.225 0.792 _IDLVK(gl)ESQAK_
EIF2S3 Ubiquitylation K70 -0.136 0.775 _FK(gl)NELER_
EIF2S3 Ubiquitylation K285 0.689 _GGVAGGSILK(gl)GVLK_
EIF2S3 Ubiquitylation K59 0.426 0.672 _STVVK(gl)AISGVHTVR_
EIF2S3 Ubiquitylation K80 0.618 _NITIK(gl)LGYANAK_
EIF2S3 Ubiquitylation K312 -0.523 0.555 _LMCK(gl)PIFSK_
EIF2S3 Ubiquitylation K308 -1.136 0.216 _DSEGK(gl)LMCKPIFSK_
EIF2S3 Ubiquitylation K466 -0.588 0.203 _GVTIK(gl)PTVDDD_
EIF2S3 Ubiquitylation K275 0.154 _SFDVNKPGCEVDDLK(gl)GGVAGGSILK_
EIF2S3 Ubiquitylation K303 -0.429 0.020 _VGQEIEVRPGIVSK(gl)DSEGK_
EIF2S3 Ubiquitylation K121 -1.264 0.000 _SCGSSTPDEFPTDIPGTK(gl)GNFK_
EIF2S3 Ubiquitylation K90 -1.279 -0.619 _IYK(gl)LDDPSCPRPECYR_
EIF2S3 Ubiquitylation K391 0.111 _LLGVRTEGDKK(gl)_

Background Information for EIF2S3:


Pubmed-EIF2S3 »
Uniprot-EIF2S3 »
Biogrid-EIF2S3 »
ProteomicsDB-EIF2S3 »

Tumorportal-EIF2S3 »
COSMIC-EIF2S3 »
GenomeRNAi-EIF2S3 »
Genecards-EIF2S3


Protein-protein Interactions for EIF2S3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF2S2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2S3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Transl_B-barrel IPR009000 0.24
Category members Transl_elong_EFTu/EF1A_2 IPR004161 0
Category members Transl_elong_EF1A/Init_IF2_C IPR009001 0


Protein complexes (CORUM database) featuring EIF2S3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5183 DNA-PK-Ku-eIF2-NF90-NF45 complex Database 0.83


Categories featuring EIF2S3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0


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