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Query: EIF2B5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2B5 0 -0.580 -0.630 0.250 -0.711 0.154 -0.822

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2B5 Phosphorylation S544 0.200 0.349 _GGS(ph)PQM(ox)DDIK_

Background Information for EIF2B5:


Pubmed-EIF2B5 »
Uniprot-EIF2B5 »
Biogrid-EIF2B5 »
ProteomicsDB-EIF2B5 »

Tumorportal-EIF2B5 »
COSMIC-EIF2B5 »
GenomeRNAi-EIF2B5 »
Genecards-EIF2B5


Protein-protein Interactions for EIF2B5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CA14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR183 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILVBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM206 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTI1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2B5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Nucleotide-diphossugar_trans IPR029044 0.21
Category members W2_domain IPR003307 0.04
Category members Trimer_LpxA-like IPR011004 0


Protein complexes (CORUM database) featuring EIF2B5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF2B5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members GO Category GO:0014003 oligodendrocyte development Database 0.21
Category members GO Category GO:0042552 myelination Database 0.16
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0031369 translation initiation factor binding Database 0.1
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members GO Category GO:0048708 astrocyte differentiation Database 0.04
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Disease phenotype Cree_leukoencephalopathy Cree leukoencephalopathy Database 0
Category members Disease phenotype Late_infantile_CACH_syndrome Late infantile CACH syndrome Database 0
Category members Disease phenotype LEUKOENCEPHALOPATHY_WITH_VANISHING_WHITE_MATTER LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER Database 0
Category members Disease phenotype OVARIOLEUKODYSTROPHY OVARIOLEUKODYSTROPHY Database 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005851 eukaryotic translation initiation factor 2B complex Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0009408 response to heat Database 0
Category members GO Category GO:0014002 astrocyte development Database 0
Category members GO Category GO:0032057 negative regulation of translational initiation in response to stress Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0045948 positive regulation of translational initiation Database 0


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